紫杉醇联合替吉奥与单药替吉奥方案用于胃癌术后辅助化疗的临床研究

Clinical study of paclitaxel combined with tiggio and monotherapy for the postoperative adjuvant chemotherapy for gastric cancer

目的探析紫杉醇联合替吉奥与单药替吉奥方案用于胃癌根治术后辅助化疗的临床效果。方法选取2014年5月~2016年5月本院收治的行胃癌根治术60例患者为研究资料,按照双盲法将其分两组,每组30例。予以对照组采取单用替吉奥方案,予以研究组采取替吉奥联合紫杉醇方案,观察比较不同治疗方案对胃癌术后辅助化疗的影响。结果通过对比两组患者的治疗失败的时间(TTF)能够看出,研究组的治疗失败的时间明显高于对照组,差异显著具有统计学意义(P<0.05);通过对比两组患者近1年的无复发生存率(RFS)情况能够看出,研究组的复发情况明显低于对照组,差异明显具有统计学意义(P<0.05);在对照组与研究组患者中,肝肾功能受损和骨髓抑制、末梢神经毒性和口腔黏膜炎及胃肠道反应等,均属于常见不良反应现象。对照组胃肠道反应和骨髓抑制反应情况显著低于研究组,组间数据差异存在统计学意义(P<0.05)。结论对于胃癌根治术后患者,单药替吉奥方案和紫杉醇联合替吉奥方案都属于有效安全的辅助化疗方案,相比单药替吉奥方案,对有较好依从性患者采取紫杉醇联合替吉奥方案,所取得的效果更佳。

Objective To investigate the clinical effect of paclitaxel combined with tiggio and monotherapy tiglio regimen for adjuvant chemotherapyafter radical gastrectomy.Methods From May2014to May2016in our hospital for treatment of radical gastrectomy60patients for the study data,according to double-blind method to divide it into two groups,each group of30cases.The rats in the control group were treated with tiggio aloneand the study group was treated with tiggio combined with paclitaxel to observe the effect of different treatment regimens on postoperative adjuvantchemotherapy for gastric cancer.Results By comparing the time of treatment failure(TTF)between the two groups,it was clear that the duration oftreatment failure in the study group was significantly higher than that in the control group(P<0.05).By comparing the two groups(P<0.05).In thecontrol group and the study group,the liver and kidney function were impaired(P<0.05).The recurrence of the study group was significantly lowerthan that of the control group(P<0.05).And bone marrow suppression,peripheral nerve toxicity and oral mucositis and gastrointestinal reactions,arecommon adverse reactions.The gastrointestinal reaction and myelosuppression response in the control group were significantly lower than those in thestudy group,and there was significant difference between the two groups(P<0.05).Conclusion For patients with gastric cancer after radical surgery,monotherapy Tiggio and paclitaxel combined with tiggio program are effective and safe adjuvant chemotherapy regimen,compared with singledrug ti giorgio program,for patients with better compliance with paclitaxel combined with solid Austrian program,the effect achieved better.