神经节苷脂在改善新生儿缺氧缺血性脑病脑血流及神经功能指标中的效果

Effect of Gangliosides in Improving the Cerebral Blood Flow and Nerve Function Indexes of Newborns with Hypoxic Ischemic Encephalopathy

目的分析神经节苷脂在改善新生儿缺氧缺血性脑病脑血流及神经功能指标中的效果.方法选取2015年3月至2016年10月期间攀枝花市妇幼保健院收治的68例缺氧缺血性脑病新生儿为研究对象,将其随机分为对照组34例和观察组34例,对照组进行常规缺氧缺血性脑病治疗,观察组则进行常规治疗加神经节苷脂,然后将2组患者治疗前和治疗后1周及2周的大脑中动脉及前动脉的脑血流参数及血清神经功能指标进行检测,并将2组不同时间的检测结果分别比较.结果治疗前2组患者的大脑中动脉及前动脉的脑血流参数及血清神经功能指标比较,P>0.05,而治疗后1周及2周观察组的大脑中动脉及前动脉的脑血流参数均高于对照组,血清神经功能指标则均低于对照组,P<0.05.结论神经节苷脂可显著地改善新生儿缺氧缺血性脑病脑血流及神经功能指标,因此在此类新生儿中具有较高的应用价值.

Objective To study and analyze the effect of gangliosides in improving the cerebral blood flowand nerve function indexes of newborns with hypoxic ischemic encephalopathy.Methods Sixty-eight newborns withhypoxic ischemic encephalopathy in our hospital from March2015to October2016were selected as the study object,and they were randomly divided into control group(34cases)and observation group(34cases).The control group wastreated with conventional treatment of hypoxic ischemic encephalopathy,the observation group was treated withconventional treatment and gangliosides,then the middle cerebral artery and anterior cerebral artery cerebral bloodflow parameters and serumnerve function indexes of two groups before the treatment and at first and second week afterthe treatment were detected,and the detection results of two groups at different time points were respectivelycompared.Results The middle cerebral artery and anterior cerebral artery cerebral blood flow parameters and serumnerve function indexes of two groups before the treatment were compared,allP>0.05,and the middle cerebralartery and anterior cerebral artery cerebral blood flow parameters of observation group at first and second week afterthe treatment were all higher than the results of control group,and serum nerve function indexes were all lower thanthe results of control group,allP<0.05.Conclusion The gangliosides can significantly improve the cerebral bloodflow and nerve function indexes of newborns with hypoxic ischemic encephalopathy,so the application value of gangliosides in these newborns is higher.