影响老年2型糖尿病患者骨质疏松症发生的多因素分析

Multivariate Analysis of the Influence Factors of Osteoporosis in Elderly Patients with Type 2 Diabetes Mellitus

目的阐明导致老年2型糖尿病患者发生骨质疏松症的相关因素,为今后预防和治疗老年2型糖尿病患者骨质疏松症提供一定的指导建议.方法随机选择121例老年2型糖尿病患者,根据中国骨质疏松症诊疗指南把121例患者分成2组(其中病例组53例,正常组68例),收集2组患者性别、年龄、体重指数、生活及活动方式(有氧活动、吸烟、饮酒、体力活动、饮食失衡、服用钙剂)、血脂、肾功、甲状旁腺、钙磷乘积、C反应蛋白、糖尿病并发症、用药情况进行比较分析.结果病例组和正常组年龄、BMI、糖尿病病程、甲状旁腺、尿素氮、肌酐、尿蛋白、有氧活动、服用钙剂、单纯胰岛素治疗差异均有统计学意义(P<0.05).结论年龄、糖尿病病程、甲状旁腺、尿蛋白为老年2型糖尿病患者骨质疏松症发生的危险因素,主动有氧活动、服用钙剂为老年2型糖尿病患者骨质疏松发生的保护因素.

Objectives To clarify the related factors of osteoporosis in elderly patients with type2diabetes mellitus and to provide guidance for the prevention and treatment.Methods A total of121elderly patients with type2diabetes were divided into2groups according to China osteoporosis guidelines:case group(n=53)and normal group(n=68).Different types of data,gender,age,body mass index(BMI),life activities(aerobic exercise,smoking,drinking,physical activity,diet imbalance,calcium),blood lipid,renal function,parathyroid hormone,calcium phosphorus product,C reactive protein,diabetic complications,and medications were collected and compared.Results There were significant differences between the two groups in age,BMI,duration of diabetes,parathyroid hormone,urea nitrogen,creatinine,urinary protein,aerobic activity,calcium and insulin treatment(P<0.05).Conclusion Age,duration of diabetes,parathyroid and urinary protein are the risk factors of osteoporosis in elderly patients with type2diabetes mellitus.Active aerobic activity and intake of calciumare protective factors of osteoporosis in elderly patients with type2diabetes.