脑神经胶质瘤患者脑脊液TSGF及HGF水平对细胞外基质重构的影响

Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients

目的探讨TSGF及HGF对脑神经胶质瘤进展的影响及与细胞外基质重构相关因子的关系.方法选择到铜川矿务局中心医院神经外科就诊的84例胶质细胞瘤患者,WHOⅠ级28例,Ⅱ级患者25例,Ⅲ级患者20例,Ⅳ级患者10例,对各级患者脑脊液TSGF及HGF、MMP-2、TIMP-2、MMP-2/TIMP-2进行检测.结果Ⅱ级患者脑脊液TSGF及EGF较Ⅰ,Ⅲ级患者TSGF及EGF较Ⅰ级、Ⅱ级,Ⅳ级患者TSGF及EGF较Ⅰ级、Ⅱ级、Ⅲ级均出现显著升高,差异有统计学意义(P<0.05).Ⅱ级患者MMP-2、TIMP-2及其比值较Ⅰ级差异有统计学意义(P<0.05),Ⅲ级患者MMP-2、TIMP-2及其比值较Ⅰ级、Ⅱ级差异有统计学意义(P<0.05),Ⅳ级患者MMP-2、MMP-2/TIMP-2较Ⅰ级、Ⅱ级、Ⅲ级差异有统计学意义(P<0.05),TIMP-2较Ⅰ级、Ⅱ级差异有统计学意义(P<0.05).TSGF与MMP-2、MMP-2/TIMP-2呈正相关,与TIMP-2负相关(P<0.05),EGF与MMP-2、MMP-2/TIMP-2呈正相关,与TIMP-2负相关(P<0.05).结论神经胶质瘤患者脑脊液内TSGF及HGF水平升高与神经胶质瘤分级密切相关,细胞外基质重构相关因子可能参与该过程,密切监测上述因子有助于协助判断神经胶质瘤进展.

Objective To investigate the effects of TSGF and HGF in CSF on ECM remodeling in glioma patients.Methods83cases of neurosurgery glioblastoma patients including gradeⅠ28cases,25cases of patients with gradeⅡ,Ⅲgrade20cases,Ⅳgrade10patients were enrolled.TSGF and EGF,MMP-2,TIMP-2,MMP-2/TIMP-2were detected.Results TSGF and EGF in patients with gradeⅡcompared withⅠappeared significantly higher level(P<0.05),TSGF and EGF ofⅢgrade patients compared with gradeⅠ,Ⅱgrade were significantly higher(P<0.05),TSGF and EGF ofⅣgrade compared with gradeⅠ,Ⅱgrade,gradeⅢwere significantly(P<0.05).MMP-2,TIMP-2,MMP-2/TIMP-2in gradeⅡpatients was significantly different than that in gradeⅠ(P<0.05),MMP-2,TIMP-2,MMP-2/TIMP-2in stageⅢpatients compared withⅠ,Ⅱsignificantly different(P<0.05),MMP-2,MMP-2/TIMP-2in stageⅣcompared with gradeⅠ,Ⅱgrade,gradeⅢshowed significant difference(P<0.05),TIMP-2compared with gradeⅠ,Ⅱgrade showed significant difference(P<0.05).TSGF with MMP-2,MMP-2/TIMP-2showed significant positive correlation while showed negative correlation with TIMP-2(P<0.05),EGF and MMP-2,MMP-2/TIMP-2showed significant positive correlation while showed negative correlation with TIMP-2(P<0.05).Conclusion Elevated cerebrospinal fluid levels of HGF and TSGF are an important factors leading to gliomas progress,the process of ECMremodeling-related factors are closely related to the progress,close monitoring those factors could help to makeclear tumor progress.