不同离体组织射频消融气化范围与凝固灶范围的对比研究

Comparative Study of Gasification Ranges and Radiofrequency Ablation Lesions in Different Tissues in Vitro

目的多时间段和多种功率对离体猪肌肉、肝脏组织进行射频消融,测量其气化范围与消融灶范围的差异,探讨不同组织气化范围与消融灶范围的关系。方法对新鲜猪肌肉(外脊)、肝(各54块)行射频消融,按消融功率和时间将实验材料分成9组,每组6个消融灶。实验重复3次,分别测量超声引导下气化范围和消融灶最大切面的纵径、横径及厚径,并计算体积,以比较气化范围与消融灶的差异。结果相同时间、相同功率下,猪肌肉消融灶的体积变化范围显著大于猪肝脏消融灶体积。超声气化范围与消融灶大小相关,肌肉组织中二者相关系数r=0.624,P<0.000;肝脏组织二者相关系数r=0.422,P<0.000。猪肌肉与肝脏RFA后,同一组织气化范围多大于消融范围,且肌肉组织气化范围与消融范围的差值显著性小于肝脏组织差值。结论相同条件下,不同组织射频消融体积不同,不同组织气化范围与消融范围差值不同。

Objective To explore the relationship between gasification range and the range of ablation in different tissues,radiofrequency ablation was used on swine muscle and liver tissues in vitro at different times with different powers.Methods Fresh swine muscle(outer ridge)and livers(each54)were divided into9groups(6ablation lesions in each group).The experiment was repeated three times,we measured respectively the longitudinal,transverse and thick diameters of the maximum cross section of the gasification range and the ablation range,and then the volume was calculated so as to compare the differences between the volume of ablation area and the range of gasification,after carrying out radiofrequency ablation on these experimental materials.Results Under the same time and power,the range of volume change of swine muscle ablation was obviously larger than that of the liver ablation.Gasification ranges were related with radiofrequency ablation lesions and the correlation coefficient in the muscle tissue was r=0.624,P<0.000,while the correlation coefficient in the liver tissue was r=0.422,P<0.000.After carrying out radiofrequency ablation on swine muscle and livers,the gasification range was greater than the lesion of ablation in the same tissue and the difference value between gasification range and ablation range in the muscle tissue was apparently smaller than that of the liver tissue.Conclusion Under the same conditions,the radiofrequency ablation volume in different tissues is different.The difference value of gasification range and ablation range is different.