人骨肉瘤发生的分子基础和潜在治疗靶点

Molecular Pathogenesis Basis of Human Osteosarcoma and Potential Targets for Therapy

骨肉瘤是骨原发性恶性肿瘤中最多见的一种,转移率高且预后极差,对该病发生机制的分子生物学水平研究结果显示:骨肉瘤的致病因素有成骨分化缺陷、癌基因和抑癌基因的异常表达及信号通路异常.现对与骨肉瘤发生、发展相关的出现异常活动的基因、蛋白、细胞因子、炎性因子、受体等潜在治疗靶点进行综述.

Osteosarcoma,with high migration and poor prognosis,is one of the most common primary malignant bone tumors.For the disease mechanism of molecular biology level studies have advanced,the cause can be divided into three directions:osteogenesis differentiation defect,abnormal expression of oncogenes and tumor suppressor genes,and abnormal signal path.This paper briefly describes the gene,protein,cell factor,inflammatory cytokines,receptors and so on with abnormal activities related to the occurrence and development of osteosarcoma,which can be the potential therapeutic target.