左氧氟沙星治疗AECOPD下呼吸道细菌感染的安全性与有效性分析

Safety and effectiveness of levofloxacin in the treatment of lower respiratory tract bacterial infection in AECOPD

目的探讨左氧氟沙星治疗AECOPD下呼吸道细菌感染临床有效性、安全性。方法选取浙江省台州医院于2016年7月～2017年4月收治的78例AECOPD下呼吸道细菌感染患者，随机分为对照组和研究组，每组39例。研究组在常规治疗基础上加用左氧氟沙星，对照组在常规治疗基础上加用头孢曲松钠，比较2组患者治疗有效性、安全性和治疗费用。结果研究组总有效率为87.18%、对照组为89.74%，2组差异无统计学意义；2组恶心呕吐、头晕、药物疹等不良反应发生率对比差异均无统计学意义；研究组左氧氟沙星使用相关费用显著少于对照组头孢曲松钠所需相关费用，差异有统计学意义（P＜0.05）。结论左氧氟沙星治疗AECOPD下呼吸道细菌感染具有较为理想的临床有效性、安全性、经济性，有利于保障患者生活质量、生命安全。

Objective To investigate the clinical efficacy and safety of levofloxacin in the treatment of AECOPD lower respiratory tract bacterial infection.Methods A total of78patients with AECOPD lower respiratory tract bacterial infection admitted in Taizhou Hospital of Zhejiang Province from July2016to April2017were randomly divided into control group and study group,39cases each group.The study group were treated with levofloxacin,the control group were treated with ceftriaxone sodium.The effect,safety and costs in the two groups were compared.Results The total effective rate was87.18%in the study group,89.74%in the control group,the difference had no statistically significant.Nausea and vomiting,dizziness,rash and other adverse drug reaction rate in the two groups had no significant difference.tThe costs associated with levofloxacin in the study group was significantly less than the cost of ceftriaxone sodium in the control group,the difference had statistically significant(P<0.05).Conclusion The use of levofloxacin in the treatment of AECOPD lower respiratory tract bacterial infection has better clinical efficacy,safety and economy,and is beneficial to protect the quality of life and life safety of patients.