经颅超声溶栓联合阿托伐他汀钙治疗动脉粥样硬化性脑梗死的临床疗效

Clinical efficacy of transcranial ultrasound thrombolysis combined with atorvastatin calcium in the treatment of atherosclerotic cerebral infarction

目的分析经颅超声溶栓联合阿托伐他汀钙治疗动脉粥样硬化性脑梗死的临床效果。方法选取2014年1月～2017年9月延安市洛川县医院收治的120例动脉粥样硬化性脑梗死患者为研究对象，随机分为对照组和实验组，每组各60例。2组患者均进行常规治疗，对照组给予阿托伐他汀钙，口服，每天20mg。实验组在此基础上给予经颅超声溶栓治疗，2次/天，一次为20min。比较分析实验组与对照组患者高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）及颈动脉斑块等临床指标。结果治疗后，实验组患者IMT为（1.01±0.32）mm显著小于对照组为（1.42±0.52）mm（P＜0.05）。治疗后，实验组NIHSS评分为（7.32±1.67），对照组NIHSS评分为（10.32±1.68）分（P＜0.05）。治疗后，实验组HDL-C水平为（2.14±0.23）mmol/L显著高于对照组为（1.98±0.20）mmol/L，另外，实验组总胆固醇（TC）、三酰甘油（TG）及LDL-C水平均显著优于对照组（P＜0.05）。结论经颅超声溶栓联合阿托伐他汀钙治疗动脉粥样硬化性脑梗死临床效果理想，可显著改善患者血脂水平，帮助患者恢复健康，缓解动脉粥样硬化。

Objective To study and analyze the clinical effect of transcranial ultrasound thrombolysis combined with atorvastatin calcium in the treatment of atherosclerotic cerebral infarction.Methods Selected120patients with atherosclerotic cerebral infarction during January2014to September2017treated in Luochuan County Hospital were divided into control group and experimental group,60cases in each group.The two groups were treated with routine treatment,and the control group was given atorvastatin calcium,20mg per day,oral.The experimental group received transcranial ultrasound thrombolysis on the basis of control group,2times per day,once for20minutes.The clinical indicators such as high-density lipoprotein cholesterol,total cholesterol and carotid plaque index were compared and analyzed in the experimental group and the control group.Results After treatment,the IMT in the experimental group was(1.01±0.32)mm significantly smaller than that in the control group(1.42±0.52)mm(P<0.05).After treatment,the score of NIHSS in the experimental group was(7.32±1.67),and the score of NIHSS in the control group was(10.32±1.68),with statistical difference(P<0.05).After treatment,the experimental group HDL-C level(2.14±0.23)mmol/L,significantly higher than the control group(1.98±0.20)mmol/L.In addition,the average level of total cholesterol,triglyceride and LDL-C in the experimental group was better than the control group(P<0.05).Conclusion Transcranial ultrasound thrombolysis combined with atorvastatin calcium in the treatment of atherosclerotic cerebral infarction clinical effect is ideal,can significantly improve the lipid level of patients,help patients recover,alleviate atherosclerosis.