重组人干扰素α2β栓治疗HPV感染的临床观察

Clinical observation of recombinant human interferonα2βsuppository in the treatment of HPV infection

目的分析重组人干扰素α2β栓治疗HPV感染的临床疗效。方法选取2015年1月～2016年12月100例医院诊治的经实验室检查确诊为HPV感染的患者，按照数字表法随机分为观察组与对照组，每组50例。观察组采用重组人干扰素α2β栓治疗，对照组则采用聚甲酚磺醛阴道栓治疗。比较2组患者的临床疗效，并比较2组患者治疗前后病毒载量变化，同时记录2组患者治疗期间的不良反应发生率。结果观察组的治疗有效率显著高于对照组（P＜0.05）；2组患者治疗前后病毒载量比较差异均有统计学意义（P＜0.05），观察组病毒载量降低量显著高于对照组（P＜0.05）；2组患者治疗期间均无明显不良反应。结论重组人干扰素α2β栓在HPV感染中具有较好的临床疗效，能够有效提高病毒清除效率、降低病毒载量，并且具有较高的安全性。

Objective To analyze the clinical efficacy of recombinant human interferon alpha2beta suppository in the treatment of HPV infection.Methods100cases of hospital diagnosis and treatment of laboratory diagnosis of HPV infection from January2015to December2016were randomly divided into observation group and control group according to the digital table method,each group50cases.The observation group was treated with recombinant human interferon alpha2beta suppository treatment,control group with treatment of Policresulen Vaginal Suppository.The clinical efficacy of the two groups was compared and the changes of viral load before and after treatment were compared between the two groups.Meanwhile,the incidence of adverse reactions in the two groups during the treatment period was recorded.Results The effective rate of the observation group was significantly higher than the control group(P<0.05);two groups of patients before and after treatment of viral load differences were statistically significant(P<0.05),the observation group decreased viral load was significantly higher than the control group(P<0.05);during the two groups of patients had no obvious adverse reaction.Conclusion Recombinant human interferon alpha2beta suppository has good clinical efficacy in HPV infection,the virus can effectively improve the removal efficiency and reduce viral load,and high safety,is worthy of clinical application.