新生儿败血症临床特征和菌谱耐药分析

Analysis of clinical features and bacterial spectrum drug-resistance in neonatal sepsis

目的探讨新生儿败血症临床特征及菌谱耐药特点。方法选择余姚市人民医院2010年1月～2015年12月收治的新生儿败血症200例，均行血培养，统计病原菌构成比，观察早发型、晚发型病原菌分布情况，并分析菌谱耐药率。结果共分离出病原菌200株，革兰阴性菌28株，占14.00%，以肺炎克雷伯杆菌、大肠埃希菌最为常见；革兰阳性菌172株，占86.00%，以金黄色葡萄球菌、表皮葡萄球菌最为多见。113株为早发型败血症病原菌，占56.5%；87株为晚发型败血症病原菌，占43.5%。结论通过分析新生儿败血症菌谱耐药特点，针对性对治疗用药进行选择，可最大程度改善预后。

Objective To investigate the clinical features,bacterial spectrum drug-resistance of neonatal sepsis.Methods200cases of neonatal septicemia in Yuyao People's hospital of Zhejiang Province from January2010to December2015were treated by blood culture,counting the constituent ratio of pathogens,the early and late-onset pathogen bacteria distribution observation and drug-resistance rate of bacteria spectrum analysis.Results A total of200strains of bacteria were isolated,28strains of gram negative bacteria accounted for14.00%,with pulmonary Bauman Acinetobacter,Escherichia coli were the most common sterilization;172strains of gram positive bacteria accounted for86.00%,Staphylococcus aureus,Staphylococcus epidermidis were the most common.113strains were early-onset septicemia pathogens,accounting for56.5%;87were lateonset septicemia pathogens,accounting for43.5%.Conclusion Through the analysis of the characteristics of bacterial spectrum drug-resistance of neonatal sepsis,targeted treatment options,could maximize the prognosis.