氟西汀联合小剂量奥氮平治疗重度抑郁症的效果分析

Effect of fluoxetine combined with low dose olanzapine in the treatment of severe depression

目的分析氟西汀联合小剂量奥氮平治疗重度抑郁症的临床效果。方法选取2015年7月～2017年5月宁波市精神病院收治的100例重度抑郁症患者为研究对象，随机分为对照组和实验组，每组各50例。对照组给予氟西汀治疗，起始剂量为20mg/d，口服。实验组在此基础上给予小剂量奥氮平治疗，初始剂量为2.5mg～5.0mg/d，晚上睡觉前口服。比较分析实验组与对照组患者的临床治疗效果、不良反应比较、HADM评分等临床指标。结果经过对应的治疗后，实验组患者的HADM评分为（14.56±2.10）分显著低于对照组评分为（24.50±3.22）分，差异具有统计学意义（P＜0.05）。实验组中，痊愈患者为27例，显效患者为12例，有效8例。对照组中，无效患者为11例。可得，实验组治疗有效率为94.0%显著高于对照组有效率为78.0%，差异具有统计学意义（P＜0.05）。实验组中，2例患者发生头晕，2例发生嗜睡。对照组中，3例发生嗜睡，2例头晕。可得，实验组与对照组不良反应发生率分别为8.0%与10.0%，差异无统计学意义。结论氟西汀联合小剂量奥氮平治疗重度抑郁症的临床疗效理想，可显著降低发生不良反应概率，安全性高，改善不良情绪。

Objective To study and analyze the clinical efficacy of fluoxetine combined with low dose olanzapine in the treatment of severe depression.Methods Selected100cases of severe depression from July2015to May2017in Ningbo Psychiatry Hospital as the research object and were randomly divided into control group and experimental group,50cases in each group.The control group was treated with fluoxetine,the initial dose of20mg/d,oral.The experimental group received a low dose of olanzapine on the basis of control group,with an initial dose of2.5mg to5.0mg/d and orally before bedtime.The clinical efficacy,side effects,HADM score and other clinical indexes of the experimental group and the control group were compared and analyzed.Results After the corresponding treatment,the HADM score of the experimental group was(14.56±2.10)points,significantly lower than that of the control group(24.50±3.22)points,the difference with statistical significance(P<0.05).In the experimental group,27patients were cured,12patients were markedly effective,and8patients were effective.In the control group,11patients were invalid.The effective rate of the experimental group was94%,which was significantly higher than that of the control group,and the effective rate was78%,which was statistically significant(P<0.05).In the experimental group,dizziness occurred in2patients and drowsiness occurred in2cases.In the control group,drowsiness occurred in3cases and dizziness in2cases.The incidence of adverse reactions in the experimental group and the control group was8%and10%respectively,which was not statistically significant.Conclusion Fluoxetine combined with low dose olanzapine is effective in the treatment of severe depression,can significantly reduce the incidence of adverse reactions,high safety and improve bad mood.