三联药物与托烷司琼联用、地塞米松联合托烷司琼对高致吐风险化疗呕吐的预防效果对比

Comparison of effective of Triple drug(Laura Si,diphenhydramine and haloperidol)combined with tropisetron dexamethasone combined with tropisetron on prevention of contrast effect of high emetogenic chemotherapy vomiting

目的分析比较三联药物（劳拉西泮、苯海拉明、氟哌啶醇）联合托烷司琼与地塞米松联合托烷司琼预防高致吐风险化疗呕吐的效果。方法观察组给予化疗前30min滴注托烷司琼，化疗前4d给予劳拉西泮、苯海拉明、氟哌啶醇；对照组给予化疗前30min静脉滴注托烷司琼，在化疗当天给予地塞米松。采用止吐问卷的方式和生活功能指数问卷的方式，对患者的呕吐控制情况、生活质量情况、急性或者延迟性呕吐的控制情况加以调查。结果2组患者，在急性恶心、急性呕吐的控制方面比较差异不大。但是观察组在延迟性恶心程度控制方面要好于对照组（P＜0.05)。结论劳拉西泮、苯海拉明、氟哌啶醇联合托烷司琼对比地塞米松联合托烷司琼预防高致吐风险化疗后的恶心呕吐的疗效更好。

Objective To compare the curative effect of Laura Si,diphenhydramine and haloperidol combined with tropisetron and dexamethasone combined with tropisetron on treatment of vomiting due to high emetogenic chemotherapy.Methods The observation group received chemotherapy for half an hour before the infusion of tropisetron,given Laura Si,diphenhydramine and haloperidol four days before chemotherapy;the control group was given chemotherapy for half an hour before the intravenous infusion of tropisetron and dexamethasone in the day of chemotherapy.The antiemetic questionnaire and life function index questionnaire to survey on patients with vomiting control,quality of life,acute or delayed vomiting control.Results There was little difference between the two groups in the control of delayed nausea and acute vomiting.But thecontrol group in the delayed nausea degree of control is better than the observation group(P0.05).Conclusion Lorazepam,diphenhydramine and haloperidol combined with tropisetron compared with dexamethasone combined with tropisetron on prevention of nausea and vomiting caused by vomiting curative effect is good high risk after chemotherapy.