酚妥拉明联合多巴胺对重症肺炎患儿的疗效及安全性研究

Effect and safety of Phentolamine combined with Dopamine on treatment of severe pneumonia in children

目的研究酚妥拉明联合多巴胺对重症肺炎患儿疗效及安全性的影响。方法选取2014年5月～2016年7月银川市第三人民医院收治的重症肺炎患儿94例，根据随机数字表法分为观察组47例，对照组47例。其中对照组行常规治疗，观察组则在对照组的基础上加用酚妥拉明联合多巴胺治疗。分别对比2组疗效，各项临床症状消失时间，治疗前后APACHEⅡ评分以及不良反应发生情况。结果观察组治疗总有效率为93.62%（44/47），高于对照组的76.60%（36/47），差异具有统计学意义（P＜0.05）。观察组患儿各项临床症状消失时间中，咳嗽消失时间为（5.1±1.5）d，发热消失时间为（3.1±1.2）d，啰音消失时间为（5.4±1.3）d，气促消失时间为（2.3±1.1）d，均分别低于对照组的（9.4±3.1）d、（6.6±1.7）d、（9.2±1.6）d、（4.9±1.4）d，差异具有统计学意义（P＜0.05）。治疗后2组APACHEⅡ评分均显著下降，而观察组又显著低于对照组，差异具有统计学意义（P＜0.05）。观察组不良反应发生率为8.51%（4/47），低于对照组的27.66%（13/47），差异具有统计学意义（P＜0.05）。结论酚妥拉明联合多巴胺治疗重症肺炎患儿的疗效显著，有利于改善患儿临床症状，减轻细胞炎症反应，具有较好的安全性。

Objective To study the effect of Phentolamine combined with Dopamine on the efficacy and safety of children with severe pneumonia.Methods94cases of severe pneumonia treated by the third People's hospital of Yinchuan city from May2014to July2016were selected as study objects,and47cases were divided into the observation group according to the random number table method,and47cases in the control group.The control group was treated with routine treatment,and the observation group was treated with Phentolamine combined with Dopaminergic therapy on the basis treatment of the control group.Curative effect,the clinical symptoms disappear time,the APACHEⅡratings before and after treatment and adverse reactions of two groups were compared.Results The total effective rate of the observation group was93.62%(44/47),compared with76.60%(36/47)in the control group,with significant difference(P<0.05).Various clinical symptoms disappear time,cough disappeared time in the observation group was(5.1±1.5)d,fever disappeared time was(3.1±1.2)d,then the sound disappear time wass(5.4±1.3)d,shortness of breath disappear time was(2.3±1.1)d,these were respectively lower than in the control group(9.4±3.1)d,(6.6±1.7)d,(9.2±1.6)d,(4.9±1.4)d,with significant difference(P<0.05).APACHEⅡscores in the two groups after treatment were significantly decreased,while the observation group was significantly lower than the control group,the differences were statistically significant(P<0.05).The adverse reaction rate of the observation group was8.51%(4/47),compared with27.66%(13/47)of the control group,with significant difference(P<0.05).Conclusion The effect of Phentolamine combined with Dopamine in treating children with severe pneumonia is significant,which is beneficial to improve the clinical symptoms of children and can reduce the inflammatory response of the cells,and has good safety.