摘要
Objective: The study aimed to investigate the correlation between concentration of inhaled arsenic trioxide and dynamic changes in hematotoxicity in rats. Method: Wistar rats were randomly divided into four study groups that were treated with saline(control) or arsenic trioxide at a low(0.1 mg/mL), medium(1 mg/mL), or high(10 mg/mL) dose by intratracheal instillation. Blood samples were collected for analysis at 6, 12, 24, 48, and 72 h after exposure. Results: Compared with the control group, the red blood cell distribution width decreased significantly in each exposure group and then gradually recovered. The red blood cell count only increased in the high-dose group, and the hemoglobin levels did not differ significantly between the groups. Significant decreases in the platelet count and mean platelet volume were observed in each arsenic-exposed group. White blood cell countsalso decreased significantly and then gradually recovered; this was associated with an increased percentage of lymphocytes and a decreased percentage of neutrophils. The blood cell parameter changes were related to the arsenic trioxide concentration and the observation time. Conclusion: Intratracheal instillation of arsenic trioxide affected hematopoietic differentiation in rats, leading to blood cell changes that were related to observation time and concentration.
Objective: The study aimed to investigate the correlation between concentration of inhaled arsenic trioxide and dynamic changes in hematotoxicity in rats. Method: Wistar rats were randomly divided into four study groups that were treated with saline(control) or arsenic trioxide at a low(0.1 mg/mL), medium(1 mg/mL), or high(10 mg/mL) dose by intratracheal instillation. Blood samples were collected for analysis at 6, 12, 24, 48, and 72 h after exposure. Results: Compared with the control group, the red blood cell distribution width decreased significantly in each exposure group and then gradually recovered. The red blood cell count only increased in the high-dose group, and the hemoglobin levels did not differ significantly between the groups. Significant decreases in the platelet count and mean platelet volume were observed in each arsenic-exposed group. White blood cell countsalso decreased significantly and then gradually recovered; this was associated with an increased percentage of lymphocytes and a decreased percentage of neutrophils. The blood cell parameter changes were related to the arsenic trioxide concentration and the observation time. Conclusion: Intratracheal instillation of arsenic trioxide affected hematopoietic differentiation in rats, leading to blood cell changes that were related to observation time and concentration.
出处
《国际感染病学（电子版）》
CAS
2017年第2期33-41,共9页
Infection International(Electronic Edition)
基金
supported by a grant from the Army Logistics Research Plan of China (AEP14C001)
National Natural Science Foundation of China (81472478)
Public Science and Technology Research Funds Projects of Quality Inspection (201510024)
