一步法和两步法建立5/6肾切除肾衰模型的对比研究

A comparative study of one-step and two-step approach in establishing 5/6 nephrectomy model of renal failure

目的对比一步法和两步法建立5/6肾切除肾衰模型的效果。方法使用一步法和两步法建立5/6肾切除肾衰模型,观察2组死亡率以及术后4、8、12周肌酐、尿素氮的水平。结果一步法组术后4周死亡率17.65%,二步法组术后4周死亡率29.41%,2组均成功建立肾衰模型,且术后8周2组肌酐、尿素氮水平无统计学差异。结论一步法和两步法均可成功建立5/6肾切除肾衰模型,一步法建立5/6肾切除肾衰模型死亡率可能更低。

Objective To compare the effect of one-step and two-step approach in establishing5/6nephrectomy model of renal failure.Methods One-step and two-step approach were used to establish the model of5/6nephrectomy,and the mortality rate and the levels of creatinine and urea nitrogen were recorded in the two groups at the end of week4,week8and week12after the operation.Results The mortality rate was17.65%in the one-step group at the end of the4th week,compared with29.41%in the two-step group at the same time after the operation.The renal failure models were successfully established in the two groups,and there was no significant difference in the levels of creatinine and urea nitrogen between the two groups at the end of the8th week.Conclusion One-step and two-step approach can successfully establish5/6nephrectomy model of renal failure,and the one-step approach may produce lower mortality.