妊娠早期合并甲状腺功能异常对产科并发症发生的影响分析

Effect analysis of thyroid dysfunction on complications of obstetric complications in early pregnancy

目的探讨妊娠早期合并甲状腺功能异常对产科并发症发生的影响。方法 60例妊娠早期合并甲状腺功能异常的产妇作为观察组,60例妊娠早期甲状腺功能正常的产妇作为对照组。对比两组产妇在妊娠早期抗甲状腺过氧化物酶抗体(TPOAb)、游离甲状腺素(FT4)、促甲状腺激素(TSH)的水平以及并发症的发生情况。结果观察组产妇在妊娠早期TSH水平低于对照组,FT4、TPOAb水平高于对照组,差异均具有统计学意义(t=22.310、16.056、10.607,P<0.05)。观察组产妇围生期发生妊娠期高血压率、妊娠期糖尿病率、早产率分别为11.67%、16.67%、13.33%,均高于对照组的1.67%、5.00%、3.33%,差异均具有统计学意义(P<0.05);两组产妇的胎盘早剥率、产后出血率对比,差异均无统计学意义(P>0.05)。结论妊娠早期合并甲状腺功能异常产妇尽早接受治疗可改善早期甲状腺功能,降低围生期并发症发生率。

Objective To discuss the effect of thyroid dysfunction on complications of obstetric complications in early pregnancy.Methods There were60early pregnancy patients with thyroid dysfunction as observation group,and60early pregnancy patients with normal thyroid function as control group.The levels of anti thyroid peroxidase antibody(TPOAb),free thyroxine(FT4),thyroid stimulating hormone(TSH)and complications were compared between the two groups at early pregnancy.Results The observation group had lower TSH level at early pregnancy than the control group,and higher and FT4and TPOAb level than the control group.Their difference was statistically significant(t=22.310,16.056,10.607,P<0.05).The observation group had higher incidence of perioperative gestational hypertension,gestational diabetes and premature birth rate respectively as11.67%,16.67%,13.33%than1.67%,5.00%and3.33%in the control group,and their difference was statistically significant(P<0.05).Both groups had no statistically significant difference in placental abruption rate and postpartum hemorrhage rate(P>0.05).Conclusion Early treatment for early pregnancy patients with thyroid dysfunction can improve the early thyroid function and reduce the incidence of perioperative complications.