半夏泻心汤联合三联疗法对胃溃疡患者血清炎性因子及免疫功能的影响

Effect of Banxia Xiexin decoction combined with trigeminotherapy on serum inflammatory cytokines and immune function in patients with gastric ulcer

目的探讨半夏泻心汤联合奥美拉唑、左氧氟沙星、阿莫西林三联疗法对胃溃疡患者血清炎性因子及免疫功能的影响，分析联合治疗可能作用机制。方法选取2014年1月～2015年12月就诊的胃溃疡患者110例为研究对象，采用随机数字表法分为观察组和对照组各55例，对照组采用奥美拉唑、左氧氟沙星、阿莫西林3联疗效治疗，观察组联合半夏泻心汤联合治疗，治疗8w后，比较2组血清炎性因子、免疫功能、临床疗效、HP转阴率等指标。结果观察组有效率、HP转阴率均明显高于对照组（96.36%vs.83.64%，92.73%vs.78.18%（χ2=4.949，4.681，P＜0.05）；血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6(IL-6)、超敏C反应蛋白（hs-CRP）含量均明显低于对照组（t=4.281，8.592，10.603，P＜0.05，P＜0.01）；T淋巴细胞亚群CD3+、CD4+、CD4+/CD8+明显高于对照组，CD8+明显低于对照组（t=3.851，12.367，2.481，5.086；P＜0.05，P＜0.01）。结论半夏泻心汤联合奥美拉唑、左氧氟沙星、阿莫西林三联疗法有助于提高胃溃疡患者临床疗效，可能与调节血清炎性因子水平、改善机体免疫功能等因素有关。

Objective To study the changes and relationship of sex hormones,cytokines and bone metabolism indexes in the patients with postmenopausal osteoporosis.Methods80postmenopausal women in Baoji Central Hospital from February2015to June2017were selected and divided into two groups according to whether or not postmenopausal osteoporosis occured.The control group had no osteoporosis after menopause,and the experimental group had osteoporosis after menopause.The clinical factors such as cytokines,bone mineral density and serum sex hormones were compared between the experimental group and the control group.Results Bone mineral density in lumbar spines in the experimental group was(0.62±0.08)g/cm2,which was significantly lower than that(0.84±0.14)g/cm2in the control group(P<0.05).The serum estrogen levels in the experimental group and in the control group were(104.32±11.32)pmol/L and(153.38±15.43)pmol/L,respectively,and the difference was statistically significant(P<0.05).The level of interleukin-6in the experimental group was(116.54±17.43)pg/mL,which was significantly higher than(83.21±7.32)pg/mL in the control group(P<0.05).The levels of N-osteocalcin in the experimental group and the control group were(32.32±4.10)ng/mL and(17.43±1.90)ng/mL,respectively,the difference was statistically significant(P<0.05).Conclusion The levels of estrogen in the patients with postmenopausal osteoporosis are decreased,and the metabolic indexes are changed greatly,which leads to the aggravation of osteoporosis and the quality of life.