奥沙利铂联合胸腺肽治疗肺癌合并恶性胸腔积液的疗效

Therapeutic effect of oxaliplatin combined with thymosin in treatment of lung cancer complicated with malignant pleural effusion

目的探讨奥沙利铂联合胸腺肽治疗肺癌合并恶性胸腔积液的效果。方法选择2016年5月～2017年5月嘉兴市第一医院所收治的36例肺癌伴恶性胸腔积液患者，随机分为2组，实验组和对照组各18例。对照组给予奥沙利铂治疗，实验组在奥沙利铂治疗基础上给予胸腺肽治疗。比较2组患者的治疗有效率、免疫功能改善情况以及IL-6与TNF-α情况。结果实验组患者治疗有效率72.22%，高于对照组的治疗有效率44.44%（P＜0.05）。实验组患者经治疗之后CD3+、CD4+以及CD4+/CD8+都明显上升，而对照组患者并未出现明显改善，实验组患者免疫功能改善要优于对照组（P＜0.05）。治疗后2组患者胸腔积液中的IL-6与TNF-α均下降，但是实验组下降程度更为明显，组间比较差异具有统计学意义（P＜0.05）。结论奥沙利铂联合胸腺肽治疗肺癌合并恶性胸腔积液的效果显著。

Objective To explore the effect of oxaliplatin combined with thymosin in the treatment of lung cancer complicated with malignant pleural effusion.Methods36patients with lung cancer with malignant pleural effusion from May2016to May2017were treated with thoracic surgery in Jiaxing First Hospital.As the object of this study,all patients were randomly divided into experimental group and control group,each group of18cases.The patients in the experimental group were treated with oxaliplatin combined with thymosin,and the patients in the control group were treated with oxaliplatin only.Comparing the2groups of patients with treatment efficiency,immune function and the improvement of IL-6and TNF-alpha.Results The effective rate of treatment was72.22%in the experimental group,better than44.44%in the control group(P<0.05).After treatment,CD3+,CD4+and CD4+/CD8+were significantly increased in the experimental group,and the patients in the control group did not improve significantly,the differences between two groups was significant(P<0.05).After treatment,the levels of IL-6and TNF-αin pleural effusion were significantly lower than those in the control group(P<0.05).The degree of decline in the experimental group was significantly higher than that in the control group(P<0.05).Conclusion Oxaliplatin combined with thymosin in the treatment of lung cancer with malignant pleural effusion is effective.