泮托拉唑联合穿孔修补术治疗消化性溃疡的临床观察

Clinical observation of pantoprazole combined with perforation repair in the treatment of peptic ulcer

目的探讨泮托拉唑联合穿孔修补术治疗消化性溃疡临床疗效。方法选取天津市第四中心医院2015年2月～2017年7月收治的100例消化性溃疡患者为研究对象，随机分为2组，每组50例。实验组与对照组患者均进行单纯穿孔修补术。实验组术后禁食给予40mg泮托拉唑治疗，1天1次，静脉滴注，治疗时间为3～5d，在此基础上进食后给予40mg泮托拉唑，1天2次，100mg胶体铋剂。比较分析实验组与对照组患者的临床疗效及复发情况等临床指标。结果对照组复发率为40.0%，显著高于实验组20.0%的复发率（P＜0.05）。治疗后，实验组患者的治疗有效率94.0%,显著高于对照组的72.0%（P＜0.05）。结论泮托拉唑联合穿孔修补术治疗消化性溃疡临床效果较为理想，可显著提高临床治疗有效率，复发率较低。

Objective To investigate the clinical efficacy of perforation repair combined with pantoprazole in the treatment of peptic ulcer.Methods100cases of peptic ulcer patients treated in our hospital from February2015to July2017were selected and randomly divided into two groups,50cases in each group.The experimental group and the control group underwent simple perforation repair,the experimental group was fasted and given40mg pantoprazole treatment after the operation,one times a day,intravenous drip,the treatment time was three to five days.The experimental group was given40mg pantoprazole,two times a day,and100mg colloida bismuth.The clinical efficacy and recurrence of the experimental group and the control group were compared and analyzed.Results The recurrence ratein the control group was40.0%,which was significantly higher than20.0%in the experimental group(P<0.05).After the corresponding treatment,the effective rate of experimental group(94.0%)was significantly higher than72.0%in the control group(P<0.05).Conclusion The clinical effect of perforation repair combined with pantoprazole in the treatment of peptic ulcer is ideal,can significantly improve clinical efficiency,low recurrence rate.