牙周炎基础治疗联合西吡氯铵含漱液对患者血清肿瘤坏死因子及龈沟液中炎症因子水平的影响

Effects of basic therapy of periodontitis combined with cetylpyridinium chloride gargle on serum tumor necrosis factor and inflammatory factors in gingival crevicular fluid

目的探讨牙周炎基础治疗联合西吡氯铵含漱液对患者血清肿瘤坏死因子及龈沟液中炎症因子水平的影响。方法随机选取2015年5月～2017年5月湖州市第一人民医院收治的牙周炎患者40例作为牙周炎组，另选取同期本院收治的健康体检人员40例作为对照组，给予牙周炎组患者基础治疗，然后对2组人员的牙周状况、血清肿瘤坏死因子及龈沟液中炎症因子水平进行统计分析。结果牙周炎组患者治疗后的PD、AL、BI、PI均显著低于治疗前（P＜0.05），治疗前、治疗后的PD、AL、BI、PI均显著高于对照组（P＜0.05）；牙周炎组患者治疗后的血清TNF-α水平、龈沟液中PEG2、IL-6水平均显著低于治疗前（P＜0.05），IL-10水平显著高于治疗前（P＜0.05），治疗前、治疗后的血清TNF-α水平、龈沟液中PEG2、IL-6水平均显著高于对照组（P＜0.05），IL-10水平均显著低于对照组（P＜0.05）。结论牙周炎基础治疗联合西吡氯铵含漱液能够有效降低患者的血清肿瘤坏死因子-α水平，改善龈沟液中炎症状态。

Objective To investigate the effect of basic therapy of periodontitis combined with cetylpyridinium chloride serum on serum tumor necrosis factor and inflammatory factor in gingival crevicular fluid.Methods40patients with periodontitis admitted in our hospital from May2015to May2017were randomly selected as periodontitis group and40healthy subjects were selected as the control group.Periodontitis group of patients given basic treatment,and then periodontal status,serum tumor necrosis factor(TNF)levels and inflammatory cytokines levels in gingival crevicular fluid of two groups were statistically analyzed.Results The levels of PD,AL,BI and PI in the periodontitis group were significantly lower than those before treatment(P<0.05).Before treatment,PD,AL,BI and PI were significantly higher than those in the control group(P<0.05).The levels of serum IL-10in gingival crevicular fluid were significantly lower than those before treatment(P<0.05),and the level of IL-10in the periodontitis group was significantly higher than that before treatment(P<0.05).The levels of serum TNF-αand the levels of PEG2and IL-6in the gingival crevicular fluid were significantly higher than those in the control group(P<0.05),and the levels of IL-10were significantly lower than those in the control group(P<0.05).Conclusion The basic treatment of periodontitis combined with cetylpyridinium chloride gargle can effectively reduce the level of serum tumor necrosis factor-αand improve the inflammatory condition in gingival crevicular fluid.