注射用英夫利西单抗联合肠内营养在克罗恩病治疗中的临床效果研究

Clinical study on the effect of remicade combined with intestinal nutrition and nursing in treatment of Crohn’s disease

目的探讨注射用英夫利西单抗联合场内营养治疗克罗恩病的临床疗效。方法随机选取温州市中心医院2014年1月～2017年3月114例克罗恩病患者，并将所有患者随机分为2组，对照组采用常规的治疗，治疗组采用注射用英夫利西单抗治疗，比较2组患者的临床治疗效果，体质量、BMI和营养指标HB、ALB、ESR、CRP和CDAI变化。结果治疗组的BMI和体质量显著高于对照组（P＜0.05）。治疗组HB，ALB显著高于对照组，治疗组ESR，CRP和CDAI水平显著低于对照组（P＜0.05）。治疗组的总有效率为96.4%，高于对照组的总有效率70.7%（P＜0.05）。结论注射用英夫利西单抗联合肠内营养治疗克罗恩病具有较好的临床治疗效果，改善患者的营养吸收。

Objective To investigate the effect of remicade combined with iintestinal nutrition and nursing on the treatment of Crohn’s disease.Methods114patients with Crohn’s disease from January2014to March2017were randomly divided into two groups.The control group was treated with conventional therapy.The treatment group was treated with two groups.The clinical efficacy,body mass,BMI and nutritional indicators of HB,ALB,ESR,CRP and CDAI were analyzed in the two groups.Results The levels of BMI and body weight in the treatment group were significantly higher than those in the control group(P<0.05).The levels of HB,ALB in the treatment group were significantly higher than those in the control group,ESR,CRP and CDAI in the treatment group were significantly lower than those in the control group(P<0.05).The total effective rate was96.4%in the treatment group,higher than70.7%in the control group(P<0.05).Conclusion The use of mannatide in children with recurrent respiratory tract infection to significantly improve the clinical efficiency,reduce the cough,sore throat and other symptoms of remission time,and the disease recurrence rate has been reduced,can greatly reduce the children’s pain.