脉络膜厚度与黄斑裂孔的相关性

Correlation between choroidal thickness and macular hole

目的:探究脉络膜厚度与黄斑裂孔的相关性,为黄斑裂孔的诊断与治疗提供理论依据。方法:本研究观察对象为2015-06/2016-06于我院眼科治疗的40例单眼特发性黄斑裂孔患者以及40例正常体检人员,将特发性黄斑裂孔患者患眼(40眼)设为A组、健侧眼(40眼)设为B组,40例正常体检人员40只正常眼设为C组,通过增强深部成像的相干光断层扫描(enhanced depth image optical coherence tomography,EDIOCT)对黄斑中心凹,黄斑中心凹外1、3mm上下鼻颞四方位9个点的脉络膜厚度进行测定,分别记为SFCT、SCT_(1mm)、SCT3mm、ICT_(1mm)、ICT3mm、NCT_(1mm)、NCT_(3mm)、TCT_(1mm)、TCT3mm,并对SFCT与年龄的关系进行相关性分析。结果:A、B组平均SFCT无显著性差异,C组显著高于A、B组,差异有统计学意义(P<0.05);A、B组SCT_(1mm)、SCT3mm、ICT_(1mm)、ICT3mm、NCT_(1mm)、NCT_(3mm)、TCT_(1mm)、TCT3mm比较,差异无统计学意义(P>0.05),且C组各测量点脉络膜厚度均显著高于A、B组,差异有统计学意义(P<0.05);与年龄的相关性分析发现,A、B组SFCT与年龄无明显相关性(r=-0.065,P=0.148;r=-0.057,P=0.658),C组SFCT与年龄呈负相关(r=-0.343,P=0.041)。结论:特发性黄斑裂孔的发病机制可能与其脉络膜厚度明显降低有关,对侧健眼较正常人群脉络膜厚度也明显降低。

AIM:To explore the correlation between choroidal thickness and macular hole,and to provide a theoretical basis for diagnosis and treatment of macular hole.METHODS:This study included40cases of monocular idiopathic macular hole patients who were treated in ophthalmology of our hospital from June2015to June2016and40cases of healthy people.Sicked eyes of idiopathic macular hole patients(40eyes)were set as the Group A,uninjured side eyes(40eyes)were set as the Group B.eyes of40cases of healthy people(40normal eyes)were set as the Group C.Choroidal thickness of macular fovea,macular fovea1mm,3mm at9points,4directions in the upper,lower,nasal and temporal regions were measured through coherent optical tomography of enhanced deep imaging(enhanced depth image optical coherence tomography,EDI-OCT).They were recorded as SFCT.SCT1mm.SCT3mm.ICT1mm,ICT3mm.NCT1mm,NCT3mm,TCT1mm,TCT3mm.and correlation analysis between SFCT and age was analyzed.RESULTS:Average SFCT of Group A,B had no significant difference,data of the Group C was significantly higher than those of the Group A,B,there was statistical significance(P<0.05).SCT1mm,SCT3mm,ICT1mm,ICT3mm,NCT1mm,NCT3mm,TCT1mm,TCT3mm of the Group A,B had no significant difference(P>0.05),and choroidal thickness at each point of the Group C was significantly higher than that of Group A and B,there was statistical significance(P<0.05).Correlation analysis of age found that there was no significant correlation between SFCT and age of the Group A,B(r=-0.065,P=0.148;r=-0.057,P=0.658),SFCT of the Group C was negatively correlated with age(r=-0.343,P=0.041).CONCLUSION:The pathogenesis of idiopathic macular hole may be related to the sharp decrease of choroidal thickness,choroidal thickness of uninjured side eyes reduces more sharply than normal population and choroidal vascular metabolism reduces may be pathogenic.