150例抗菌药物不合理使用与药物不良反应发生的相关性研究

Study on the correlation between irrational use of antibiotics and adverse drug reactions in 150 cases

目的:分析探讨抗菌药物不合理使用与药物不良反应发生的相关性。方法:选取150例药物不良反应患者为研究对象,分析各抗菌药物不合理使用、不良反应发生情况及两者之间的相关性。结果:因抗菌药物所致药物不良反应的有76例(占50.67%),其中主要以喹诺酮类及β-内酰胺类药物为主。药物不良反应累及部位主要为皮肤及软组织和消化系统,抗菌药物不合理使用主要表现在给药时间过长、滴速过快、药物浓度过高及剂量过大4个方面,且均与药物不良反应发生率有显著相关性(P<0.05)。结论:抗菌药物不良反应发生的主要原因为临床不合理使用,因此应加强抗菌药物的规范应用来降低不良反应发生率。

Objective:To explore the correlation between unreasonable use of antibacterial agents and adverse drug reactions(ADR).Methods:The clinical data from150cases of patients with adverse drug reactions were retrospectively analyzed and the correlation was deduced.Results:There were76cases of adverse drug reactions(50.67%)and the majority was caused by quinolones(43.42%)andβ-lactam antibiotics(30.26%).The main parts involved by ADR were skin and soft tissue and digestive system.The main manifestations for the unreasonable use of antibacterial agents were over long transfusion time,over fast dripping,high drug concentration and overdose and they all were significantly correlated with the incidence of adverse drug reactions.Conclusion:The major reason for adverse drug reaction is unreasonable use of antibacterial agents.Therefore,the reasonable use of antibacterial agents should be strengthened so as to reduce the incidence of ADR.