1例美罗培南致血小板减少

One case of meropenem-induced thrombocytopenia

1例老年女性因慢性阻塞性肺疾病急性加重期接受美罗培南、低分子肝素治疗1 d后出现黑便、血小板减少。停用低分子肝素后,黑便好转,但血小板进一步减少,停用美罗培南后血小板逐步恢复。考虑为美罗培南引起血小板减少,联合低分子肝素导致消化道出血。

An elderly woman with acute exacerbation of chronic obstructive pulmonary disease was treated with meropenem and low molecular weight heparin.She got melena with thrombocytopenia after one day treatment.The melena status was improved but the platelets were further reduced after the heparin was discontinued,and then the platelets were progressively increased after meropenem was also discontinued.We considered that meropenem might cause thrombocytopenia,and gastrointestinal bleeding might be induced when it was used in combination with low molecular weight heparin.