东莞地区1 962例宫颈高危型人乳头瘤病毒检测及其流行病学调查分析

Detection of 1 962 cases of high-risk human papillomavirus cervix and their epidemiological investigation in Dongguan area

目的:了解东莞地区高危型人乳头瘤病毒(HR-HPV)的感染状况及年龄特征,为HR-HPV感染和宫颈癌防治提供理论依据。方法:选取我院妇科门诊女性1 962例,采用多重核酸扩增(PCR)荧光检测法对研究对象进行HPV检测,并统计分析。结果:1 962例妇科门诊女性中,HR-HPV阳性349例,占17.78%。HR-HPV阳性率依高低顺序排列的前五位分别为HPV 52、16、58、39、51。HR-HPV病例中(不排除混合感染),20~30岁年龄段为最多,其次是31~40岁年龄段。在多重感染病例中同样如此。结论:东莞地区HR-HPV阳性率在全国范围内处于较高水平,HPV 52、16、58、39、51为东莞地区常见感染亚型。

Objective:To understand the infective condition and age distribution of high-risk human papillomavirus(HR-HPV)in Dongguan area so as to provide a theoretical basis for the prevention and treatment of HR-HPV infection and cervical cancer.Methods:HPV detection was carried out by multiplex PCR fluorescence test in1962cases of outpatients selected in our hospital and their results were statistically analyzed.Results:There were349HR-HPV positive cases,accounting for17.78%and the top5ranked in descending order were HPV52,16,58,39,51in turn.Among HR-HPV positive patients,the age distribution with highest infection rate was population with20~30years old,followed by31~40years old.The same thing happened among the multiple infective patients.Conclusion:HR-HPV positive rate in Dongguan area is at a higher level in China and HPV52,16,58,39and51become the commonest subtype infection in this area.