芪归健脑方对阿尔茨海默病病人血清β-淀粉样蛋白和认知能力的影响

Effect of Qigui Jiannao Prescription on Serum amyloid-βProtein and Cognitive Ability in Patients with Alzheimer's Disease

目的探讨芪归健脑方对阿尔茨海默病(AD)病人血清β-淀粉样蛋白(Aβ)含量和认知能力的影响。方法选取60例住院的阿尔茨海默病病人,将病人分为比拉西坦(脑复康)组和芪归健脑方组,每组30例。芪归健脑方组病人服用芪归健脑方剂进行治疗,每次1g,每日2次。脑复康组服用脑复康,每次800mg,每日3次。治疗时间为6个月,分别在治疗前和治疗后检测病人血清β-淀粉样蛋白含量,病人的智力障碍情况利用简易智力状态量表评价。结果与治疗前相比,治疗后芪归健脑方组和脑复康组的血清β-淀粉样蛋白含量均显著降低,简易智力状态量表得分显著提高(P<0.05),芪归健脑方组和脑复康组治疗后相比差异无统计学意义(P>0.05),但芪归健脑方组优于脑复康组。结论芪归健脑方能提高阿尔茨海默病病人认知能力,这可能与芪归健脑方能降低阿尔茨海默病病人血清β-淀粉样蛋白的含量有关。

Objective To explore the effects and clinical significance of Qigui Jiannao prescription(QJP)on the level of serum amyloidβprotein and cognitive ability in patients with Alzheimer’s disease(AD).Methods Sixty patients with AD were collected in hospital,and randomly divided into two groups:control group(n=30)treated with Naofukang,and treatment group(n=30)treatedwith QJP for6months.The content of serum amyloid-βwere detected before and after treatment respectively,and the mental retardationdegree was evaluated by simple intelligence status scale.Results Compared with that before treatment,the serum level ofamyloid-βprotein in two groups were significantly decreased after treatment(P<0.05),while the simple mental state scale scoreswere markedly increased after treatment(P<0.05).There was no significantly differences between control group and treatmentgroup(P>0.05).Conclusion QJP can improve the cognitive abilities in patients with AD,which can improve the content of serumamyloid-βprotein in patients with AD.