探讨难治性肾病综合征采用低分子肝素联合激素、环磷酰胺治疗效果

Clinical Study on the Treatment of Refractoriness Nephrotic Syndrome with Low Molecular Weight Heparins combined with Hormone and Cyclophosphamide

目的探究难治性肾病综合征患者采用低分子肝素联合激素、环磷酰胺治疗的临床价值。方法选取我院2015年10月~2016年6月入院的难治性肾病综合征患者80例,按照随机分组法分为观察组和对照组,每组40人。对照组患者接受环磷酰胺联合激素治疗,观察组接受激素、环磷酰胺联合低分子肝素治疗,对比两组患者临床疗效,并比较24h尿蛋白定量、尿素氮及肌酐水平。结果对照组患者的临床有效率为80%,观察组的临床有效率为95%,观察组显著优于对照组;治疗后,观察组24h尿蛋白定量、尿素氮及肌酐水平改善情况明显优于对照组(P<0.05),具有统计学意义。结论难治性肾病综合征患者采用低分子肝素联合激素、环磷酰胺治疗的临床疗效十分显著,应在临床大力推广应用。

To investigate the clinical value of refractoriness nephrotic syndrome treated with low molecular weight heparins combined with hormone and cyclophosphamide.Methods:Totally,80patients with refractoriness nephrotic syndrome were admitted and treated in Dazhu Traditional Chinese Medicine Hospital from October2015to June2016.They were randomly divided into test group and control group with40patients in each group.Patients in control group were treated with cyclophosphamide combined with hormone,while patients in test group were treated with low molecular weight heparins combined with hormone and cyclophosphamide.The clinical efficacy,24-hour urine protein,urea nitrogen,and creatinine were compared in the two groups.Results:The effective rate was significant better in test group(95%)than that in control group(80%).After treatment,24-hour urine protein,urea nitrogen,and creatinine were significant better in test group than those in control group(P<0.05).Conclusions:Low molecular weight heparins combined with hormone and cyclophosphamide to treat refractoriness nephrotic syndrome has significant clinical efficacy,is worth promoting the application.