肠球菌属281株细菌的临床分布及耐药性分析

Clinical distribution and drug resistance of 281 strains of Enterococcus bacteria

目的:探讨肠球菌在临床标本中的分布特点及其对常用抗菌药物的耐药性。方法:常规分离菌株,采用MIC法进行药敏试验。结果:临床分离的281株肠球菌主要来源于尿液及腹水;以外科病房尤其是肝胆外科病房检出率最高。屎肠球菌耐药率总体高于粪肠球菌,粪肠球菌对β-内酰胺类、达托霉素、呋喃妥因、喹若酮类药物敏感性较高。结论:不同种的肠球菌耐药性有较大差异,但肠球菌属细菌对万古霉素、利奈唑胺依然保持很高的敏感性。

Objective:To investigate the distribution characteristics of enterococci in clinical specimens and their resistance to commonly used antibiotics.Methods:Conventional isolates,we used MIC method for drug susceptibility test.Results:The clinical isolates of281strains of enterococci mainly came from urine and ascites,and the detection rate was the highest in surgical wards,especially in department of hepatobiliary surgery.The resistance rate of enterococcus faecium was higher than that of enterococcus faecalis,enterococcus faecalis to beta lactams,daptomycin,nitrofurantoin,quinoline ketone if the drug sensitivity is better.Conclusion:The drug resistance of enterococci varied greatly,but Enterococcus still maintained high sensitivity to vancomycin and linezolid.