牙周病与心肌梗死相关性的Meta分析

Meta-analysis of the association between periodontal disease and myocardial infarction

目的探讨牙周病与心肌梗死的相关性。方法计算机检索PubMed、中国知网和万方数据库中公开发表的相关文献,自建库至2017年1月31日(2017年2月7日更新检索)。对符合纳入标准的文献进行数据提取和质量评价后采用R 3.3.3软件进行Meta分析。结果最终纳入32项观察性研究,其中5项队列研究、21项病例-对照研究及6项横断面研究。基于于校正的Meta分析结果显示牙周病增加心肌梗死发病风险2.09倍(OR=2.09,95%CI:1.75~2.48,P<0.01),敏感性分析结果显示稳健性好。漏斗图显示存在明显发表偏倚。结论牙周病很可能是心肌梗死的危险因素。

Objective To evaluate the association between periodontal disease and myocardial infarction.Methods The PubMed,CNKI and WanFang Databases were retrieved for collecting the relevant literature up to January31,2017(February7,2017update search).Meta-analysis was performed using R3.3.3software after data extraction and quality assessment of included studies.Results Finally,32observational studies were included:5cohort studies,21case-controlled studies,and6cross-sectional studies.All of them were high quality.Result of adjusted meta-analysis showed that periodontal disease increased risk of myocardial infarction2.09times(OR=2.09,95%CI:1.75~2.48,P<0.01),and result of sensitivity analysis showed good stability.The funnel graph showed a significant publication bias.Conclusion Periodontal disease is likely to be a risk factor for myocardial infarction.