血必净联合早期持续肾脏替代治疗对热射病患者全身炎症反应及肾功能损害的影响

Effect of Xuebijing combined with early continuous renal replacement therapy on systemic inflammatory response and renal impairment in patients with heat stroke

目的:研究血必净联合早期持续肾脏替代治疗对热射病患者全身炎症反应及肾功能损害的影响。方法:选择在本院接受治疗的24例热射病患者并随机分为两组,血必净组接受血必净联合早期持续肾脏替代治疗,对照组接受早期持续肾脏替代治疗。治疗前及治疗后3、6天时,检测两组患者血清中炎症反应细胞因子、凝血功能相关细胞因子及肾功能指标的含量。结果:两组患者治疗后3、6天时血清中TNF-α、IL-6、IL-17、hs-CRP、TF、sTM、sE-selectin、BUN、Scr、β2-MG、Cys-C的含量均显著低于治疗前且血必净组患者治疗后3、6天时血清中TNF-α、IL-6、IL-17、hs-CRP、TF、sTM、sE-selectin、BUN、Scr、β2-MG、Cys-C的含量均显著低于对照组。结论:血必净联合早期持续肾脏替代治疗能够减轻热射病患者的全身炎症反应程度及肾功能损害程度。

Objective:To study the effect of Xuebijing combined with early continuous renal replacement therapy on systemic inflammatory response and renal impairment in patients with heat stroke.Methods:A total of24patients with heat shock who were treated in Qidong People's Hospital between June2015and August2017were selected and randomly divided into two groups,Xuebijing group received Xuebijing combined with early continuous renal replacement therapy,and control group received early continuous renal replacement therapy.Serum levels of inflammatory response cytokines,coagulation related cytokines and renal function indicators of two groups of patients were detected before treatment as well as3days and6days after treatment.Results:Serum TNFα,IL6,IL17,hs CRP,TF,sTM,sE selectin,BUN,Scr,β2MG and Cys C levels of both groups3days and6days after treatment were significantly lower than those before treatment,and serum TNFα,IL6,IL17,hs CRP,TF,sTM,sE selectin,BUN,Scr,β2MG and Cys C levels of Xuebijing group3days and6days after treatment were significantly lower than those of control group.Conclusion:Xuebijing combined with early continuous renal replacement therapy can reduce the degree of systemic inflammatory response and renal impairment in patients with heat stroke.