腹膜透析患者血清维生素C含量与肾性贫血、氧化应激、微炎症状态的相关性研究

The correlation of serum vitamin C content with renal anemia,oxidative stress and microinflammatory state in patients with peritoneal dialysis

目的:探讨腹膜透析患者血清维生素C含量与肾性贫血、氧化应激、微炎症状态的相关性。方法:2016年1月~2017年1月间在苏州大学附属第一医院接受腹膜透析治疗的患者96例作为腹膜透析组,同期在苏州大学附属第一医院进行体检的健康志愿者50例作为正常对照组。检测两组研究对象外周血中VitC、肾性贫血、氧化应激、微炎症相关指标的含量,采用Pearson检验评估腹膜透析患者血清VitC含量与肾性贫血、氧化应激、微炎症状态的相关关系。结果:腹膜透析组患者外周血中VitC的含量低于正常对照组;外周血中肾性贫血相关指标血红蛋白(Hb)、红细胞数(RBC)、总铁结合力(TIBC)的水平低于正常对照组;血清中氧化应激指标LHP、髓过氧化物酶(MPO)、晚期氧化蛋白产物(AOPPs)的含量高于正常对照组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的含量低于正常对照组;血清中炎症因子C反应蛋白(CRP)、白介素(IL)-6、IL-8、IL-10、IL-13的含量高于正常对照组。腹膜透析患者血清中VitC含量与Hb、RBC、TIBC、SOD、GSH-Px的水平呈正相关,与LHP、MPO、AOPPs、CRP、IL-6、IL-8、IL-10、IL-13的含量呈负相关。结论:腹膜透析患者血清VitC含量降低,且具体含量与机体肾性贫血、氧化应激、微炎症状态严重程度直接相关。

Objective:To study the correlation of serum vitamin C content with renal anemia,oxidative stress and microinflammatory state in patients with peritoneal dialysis.Methods:A total of96patients undergoing peritoneal dialysis in the First Affiliated Hospital of Soochow University between January2016and January2017were selected as the peritoneal dialysis group,and50healthy volunteers receiving physical examination in the First Affiliated Hospital of Soochow University during the same period were selected as the normal control group.The contents of VitC as well as renal anemia,oxidative stress and microinflammation related indexes in peripheral blood of two groups of subjects were detected,and Pearson test was used to evaluate the correlation of serum VitC content with renal anemia,oxidative stress and microinflammatory state in patients with peritoneal dialysis.Results:VitC content in peripheral blood of peritoneal dialysis group was lower than that of normal control group;renal anemia related indexes Hb,RBC and TIBC levels in peripheral blood were lower than those of normal control group;oxidative stress indexes LHP,MPO and AOPPs contents in serum were higher than those of control group while SOD and GSH Px contents were lower than those of control group;inflammatory factors CRP,IL6,IL8,IL10and IL13contents in serum were higher than those of normal control group.VitC content in serum of patients with peritoneal dialysis was positively correlated with Hb,RBC,TIBC,SOD and GSH Px levels,and negatively correlated with LHP,MPO,AOPPs,CRP,IL6,IL8,IL10and IL13contents.Conclusion:Serum VitC content is lower in patients with peritoneal dialysis,and the specific content is directly correlated with the severity of renal anemia,oxidative stress and microinflammatory state.