CEA、CA125、SCC-Ag、CA199及CYFRA21-1等肿瘤标志物在宫颈癌中诊断的价值和意义

The value and significance of tumor markers such as CEA,CA125,SCC-Ag,CA199 and CYFRA21-1in diagnosis of cervical cancer

目的:通过对研究对象五种肿瘤标志物的检测比较,探讨CEA、CA125、SCC-Ag、CA199及CYFRA21-1等不同肿瘤标志物在宫颈癌中诊断的价值和意义。方法:对108例研究对象进行分组,按照疾病类型分为三组,其中包括在我院进行诊治的宫颈癌患者60名,宫颈上皮内瘤变(CIN)患者20名,同期门诊体检健康妇女28名。用放射免疫分析法检测三组研究对象的CA125、CA199和CYFRA21-1水平;用ELISA(酶联免疫吸附法)检测血清SCC-Ag、CEA水平,并进行对比。结果:(1)CIN组与健康对照组CA125、CA199、CYFRA21-1、SCC-Ag、CEA水平之间无显著性差异(P>0.05);宫颈癌组CA125、CA199、CYFRA21-1、SCC-Ag、CEA水平均明显高于健康对照组和CIN组,两组之间具有显著性差异(P<0.05)。(2)在不同组织类型宫颈癌患者中,CA125、CA199、CYFRA21-1、SCC-Ag、CEA水平的差异具有统计学意义(P<0.05)。CA125、CA199、CEA在腺癌中的含量明显高于鳞癌、鳞腺癌(P<0.05),鳞癌与鳞腺癌的比较无统计学意义(P>0.05);CYFRA21-1、SCC-Ag在鳞癌中的含量明显高于腺癌、鳞腺癌(P<0.05),腺癌与鳞腺癌的比较无统计学意义(P>0.05)。结论:宫颈癌患者中的CA125、CA199、CYFRA21-1、SCC-Ag、CEA水平明显高于宫颈上皮内瘤变患者和健康者,SCC-Ag、CYFRA21-1在宫颈鳞癌患者中水平较高,CA125、CA199、CEA对宫颈腺癌的诊断更有意义,此五种肿瘤标志物可作为宫颈癌辅助诊断的检查指标,对鉴别宫颈癌病理分型同样具有一定的价值。

Objective:Comparing serum levels of the five tumor markers among the cases,to observe the significance by detecting serum levels of CEA,CA125,SCC Ag,CA199and CYFRA211in diagnosis of cervical cancer.Methods108cases were divided intothree groups,including60cervical cancerpatients and20cervical intraepithelial neoplasiain patients our hospital from September2015to September2016and28healthy women.Radioimmunoassay was used to detect and compare the serum levels of CA125,CA199,CYFRA211and ELISA methodwas used to detect and compare the serum levels ofSCC Ag,CEA.Results(1)There was no statistically significant difference in the serum CEA,CA125,SCC Ag,CA199,CYFRA211levels between CIN group and control group(P>0.05).The serum CEA,CA125,SCC Ag,CA199,CYFRA211levels of cervical cancer patients were significantly higher than the other two groups.The differences were statistically significant(P<0.05).(2)There were statistically significant differences in the serum CEA,CA125,SCC Ag,CA199,CYFRA211levels between differentcervical pathological typegroups(P<0.05).The serum CA125,CA199,CEA levels of cervical glandular cancer patients were significantly higher than the other two groups.The differences were statistically significant(P<0.05).The serum SCC Ag,CYFRA211levels of cervical squamous cancer patients were significantly higher than the other two groups.The differences were statistically significant(P<0.05).ConclusionThe serum CEA,CA125,SCC Ag,CA199,CYFRA211levels of cervical cancer patients were significantly higher thancervical intraepithelial neoplasiain patients and healthy women.The serum CA125,CA199,CEA levels of cervical glandular cancer patients were significantly higherand the serum SCC Ag,CYFRA211levels of cervical squamous cancer patients were significantly higher.The five tumor markerscan be used in diagnosis of cervical cancer and they are also worthy in distinguishing cervical pathological types.