脑梗死患者服用阿司匹林致消化道出血相关因素分析

Correlation factors analysis of gastrointestinal bleeding induced by aspirin in patients with cerebral infarction

目的探讨脑梗死患者服用阿司匹林导致消化道出血的相关危险因素。方法回顾性分析2013年5月至2017年1月该院收治的820例服用阿司匹林的脑梗死患者的临床资料,包括性别、年龄、吸烟史、饮酒史、消化道病史、高血压病史、糖尿病病史、高脂血症史、服药时间、幽门螺杆菌(Hp)感染等情况。依据以上临床因素分组,观察各组患者消化道出血情况,并进一步分析。结果年龄(≥65岁)、服药时间大于或等于3个月、吸烟、饮酒、消化道病史、高血压病史、Hp感染阳性者服用阿司匹林后易导致消化道出血(P<0.05);年龄(≥65岁)、饮酒史、消化道病史、Hp阳性是脑梗死患者服用阿司匹林导致消化道出血的独立危险因素(P<0.05)。结论脑梗死患者服用阿司匹林有导致消化道出血的风险,高龄、饮酒史、消化道病史、高血压病史、吸烟、Hp阳性、服药时间长的患者需慎用阿司匹林。

ObjectiveTo explore the risk factors of gastrointestinal bleeding induced by aspirin in patients with cerebral infarction.MethodsRetrospective analysis was conducted on the clinical data of820patients with cerebral infarction,who were administrated with aspirin and received in the hospital from May2013to January2017,and the clinical data included gender,age,smoking history,drinking history,history of digestive diseases,history of hypertension,history of diabetes mellitus,hyperlipidemia,medication time,helicobacter pylori(Hp)infection and so on.To group the patients according to the above clinical factors,the patients with gastrointestinal bleeding were observed and analyzed statistically.ResultsThe patients,who were65years or older,with medication time no less than3months,smoking,drinking,history of digestive disease and hypertension,and Hp infection,were susceptible to gastrointestinal bleeding after administration of aspirin.Logistic regression analysis showed that old age(≥65years),drinking history,history of digestive diseases,Hp infection were the independent risk factors for gastrointestinal bleeding in patients with cerebral infarction(P<0.05).ConclusionThe patients with cerebral infarction have risk of gastrointestinal bleeding after administration of aspirin,especially to the patients with the characteristics of old age(≥65years),drinking history,history of digestive diseases and hypertension,smoking,Hp injection and long time of medication.