小儿哮喘非急性发作期IgE、EOS、LTE-4检测及其临床意义

Detection of IgE,EOS,LTE-4 of infantile asthma in non-acute stage and its clinical significance

目的探讨小儿哮喘非急性发作期血清免疫球蛋白E(Ig E)、外周血嗜酸性粒细胞(EOS)、尿白三烯E4(LTE-4)检测及其临床意义。方法选取2015年12月至2016年12月该院收治的小儿哮喘非急性发作期患儿90例作为研究对象,根据病情严重程度分为一般哮喘组(32例)、中度哮喘组(31例)和重度哮喘组(27例),另选取30例健康儿童作为对照组。90例小儿哮喘非急性发作期患儿给予不同剂量β2受体激动剂治疗,每天3~4次;适当吸入糖皮质激素联合治疗。治疗前、治疗3个月后检测患儿Ig E、EOS、LTE-4等进行疗效评估,并评价患儿临床症状改善情况。结果各组哮喘患儿治疗前Ig E、EOS、LTE-4水平均明显高于对照组,重度哮喘组患儿治疗前Ig E、EOS、LTE-4水平均明显高于一般哮喘组和中度哮喘组,中度哮喘组患儿治疗前Ig E、EOS、LTE-4水平均明显高于一般哮喘组,差异均有统计学意义(P<0.05);各组哮喘患儿治疗3个月后Ig E、EOS、LTE-4水平均明显低于治疗前,差异均有统计学意义(P<0.05),与对照组比较,差异均无统计学意义(P>0.05);重度哮喘组患儿总有效率均明显低于一般哮喘组和中度哮喘组,差异均有统计学意义(P<0.05)。结论血清Ig E、EOS、LTE-4检测可评估小儿哮喘非急性发作期患儿临床症状改善情况;治疗过程中血清Ig E、EOS、LTE-4水平呈下降趋势,与小儿哮喘非急性发作期临床症状的改善具有很强的关联性,能很好地提示小儿哮喘非急性发作期患儿的康复情况。

Objective To explore the clinical significance of serum immunoglobulin(IgE),peripheral blood eosinophils(EOS)and urinary leukotriene E4(LTE-4)in infantile asthma during non-acute stage and its clinical significance.MethodsA total of90patients with infantile asthma during non-acute stage,who were received in the hospital from December2015to December2016,were selected as research objects and divided into ordinary asthma group(n=32),moderate asthma group(n=31)and severe asthma group(n=27)according to the severity of illness.Simultaneously,30healthy children were chosen as the blank control group.90patients during non-acute stage were given different dosage ofβ-receptor agonist for treatment,combining with proper inhalation of glucocorticoid,3or4times a day.The levels of IgE,EOS and LTE-4were detected before treatment and3months after treatment for treatment evaluation,meanwhile to estimate the improvement of clinical symptoms.ResultsBefore treatment,the levels of IgE,EOS and LTE-4in the patients with asthma were evidently higher than those in the control group,the levels of IgE,EOS and LTE-4in the severe group were obviously higher than those in the ordinary group and the moderate group,the levels of IgE,EOS and LTE-4in the moderate group were remarkably higher than those in the ordinary group,and the differences had statistical significance(P<0.05).The levels of IgE,EOS and LTE-4in the ordinary group,the moderate group and the severe group after3-month treatment were obviously lower those before treatment with statistically significant difference(P<0.05),but there was no statistically significant difference after3-month treatment compare with the control group(P>0.05).The total effective rate in the severe group was distinctly inferior to that in the ordinary group and the moderate group with statistically significant difference(P<0.05).Conclusion The detection of serum IgE,EOS and LTE-4can be used to evaluate the improvement of clinical symptoms of infantile asthma during non-acute stage;the levels of serum IgE,EOS and LTE-4are in declining trend in the process of treatment,which is strong correlated with the improvement of clinical symptoms of infantile asthma during non-acute stage and it can indicate rehabilitation condition of patients.