人黑素瘤药物研究进展

Clinical treatment of human melanoma:recent progress

黑素瘤患者死亡率较高。其治疗方法除了传统的手术切除和放射治疗外,化疗一度成为主要的治疗手段。近年来,随着人们对黑素瘤发生发展分子机制的深入研究,基于靶向治疗、生物免疫治疗的方法和药物不断涌现。目前,除了已经在临床治疗中使用的药物外,一些正在进行临床研究的待批准药物和正进行基础研究的潜在药物也表现出良好的应用前景。本文就目前治疗黑素瘤的代表性药物及潜在药物的分子机制及治疗效果作一综述。

The mortality rate of melanoma is high.Chemotherapy became the main treatment during the past years besides traditional surgical excision and radiotherapy.In recent years,with the in depth study of the molecular mechanism of the occurrence and development of melanoma,new treatment methods and medicines basing on the target therapy and immune therapy have emerged constantly.At present,in addition to the drugs that have been used in clinical treatment,some of the drugs that are being approved for clinical research and the potential drugs which are still in basic research show good application prospects.In this paper,the molecular mechanism and therapeutic effect of the representative drugs or potential drugs in the treatment of melanoma were reviewed.