无锡地区62141例育龄期妇女TORCH检测结果与季节性变化的相关性分析

A correlation analysis on TORCH screening results of 62 141 women at childbearing age in Wuxi

目的通过化学发光免疫分析法检测无锡地区育龄期妇女血清TORCH抗体,并对结果按季节进行统计分析,了解无锡地区育龄妇女TORCH感染情况及其流行特点,为本地区育龄期妇女保健提供一定的参考依据。方法选择产前检查的62 141例育龄期妇女为研究对象,对TORCH病毒原体弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)、单纯疱疹病毒(HSV)进行检测。结果 TORCH四种病原体TOX、RV、CMV以及HSV的免疫球蛋白M(IgM)抗体阳性率依次为1.25‰(77/61 452)、2.66‰(163/61 381)、0.37‰(23/61 387)、129.41‰(7 872/60 829),anti-HSV IgM抗体阳性率远高于其他三种IgM抗体阳性率;anti-CMV IgM、anti-RV IgM、anti-TOX IgM、anti-HSV IgM抗体阳性率总体呈现逐年上升的趋势;统计结果显示,秋、冬季为巨细胞病毒感染高发期(anti-CMV IgM阳性检出率分别为39%、35%),而TOX、RV、HSV的感染率并无明显的季节性变化。结论育龄期妇女和医疗人员需提高对TORCH感染的季节性认识,同时有针对性的按季节性对孕妇进行TORCH检测,可及时了解孕妇TORCH感染情况,尽早采取方法和措施,对人口的优生优育具有重要意义。

Objective To analyze and detect by season serum TORCH level in women of childbearing age in Wuxi area by chemiluminescence immunoassay,to define the TORCH infection and epidemiological characteristics of women of childbearing age,and to provide reference for maternal health care in Wuxi area.MethodsStudy was conducted on62141cases of women of childbearing age in Affiliated Wuxi Women&Children Health Care Hospital of Nanjing Medical University.Four pathogens of TORCH were detected:Toxoplasma gondii(TOX),rubella virus(RV),cytomegalovirus(CMV)and human herpes virus(HSV).ResultsThe positive rates of IgM antibody of TOX,RV,CMV and HSV were1.25‰(77/61452),2.66‰(163/61381),0.37‰(23/61387)and129.41‰(7872/60829)respectively.The positive rate of anti HSV IgM antibody was much higher than the other three kinds of IgM antibody.The positive rates of anti CMV IgM,anti RV IgM,anti TOX IgM and anti HSV IgM antibodies showed a trend of rising.The incidence of CMV was high in spring and winter while the infection rate of RV,HSV and TOX had no significant relationship with the change of seasons.ConclusionsBoth women of childbearing age and medical workers need to improve the awareness of TORCH seasonal infection.Seasonal TORCH detection can reflect the infection status of women of childbearing age promptly.Early treatment has great significance to eugenics.