H型高血压患者血压晨峰现象与早期肾功能损害的关系

Relationship between morning blood pressure surge phenomenon in patients with type H hypertension and the early renal damage

目的探讨具有晨峰现象的H型高血压与早期肾功损害关系。方法选择已确诊H型高血压[同型半胱氨酸(Hcy)≥10μmol·L^(-1)]者共210例,对这些患者行24 h动态血压监测(ABPM),根据监测结果将患者分为晨峰组(108例)和非晨峰组(102例),检测各组受试者血清胱抑素C水平以及尿β2-微球蛋白的含量,同时检测一般生化指标。结果晨峰组24 h平均收缩压[(155.7±14.6)mmHg]、白昼平均收缩压[(160.4±15.5)mmHg]、夜间平均收缩压[(147.7±16.5)mmHg]、收缩压晨峰[(35.4±7.2)mmHg]、尿β2-微球蛋白[(1.11±0.31)mg·L^(-1)]及血清半胱氨酸蛋白酶抑制剂C[(1.86±1.04)mg·L^(-1)]均高于非晨峰组(P<0.05)。结论 H型高血压患者中具有血压晨峰者较非血压晨峰者更易出现早期肾功能损害。

ObjectiveTo investigate the relationship between morning blood pressure surge(MBPS)phenomenon in patients with type H hypertension and the early renal damage.MethodsTwo hundred and ten cases of type H were selected(Hcy≥10μmol·L-1)for24hour ambulatory blood pressure monitoring(ABPM),who were assigned into the MBPS group with108patients and non MBPS group with102patients according to the monitoring results.The serum cystatin C and urinary beta2microglobulin and the general biochemical indexes were detected.ResultsThe24hour mean systolic blood pressure[(155.7±14.6)mmHg],daytime average systolic blood pressure[(160.4±15.5)mmHg],nighttime average systolic blood pressure[(147.7±16.5)mmHg],morning peak systolic blood pressure[(35.4±7.2)mmHg],urine beta2microglobulin([1.11±0.31)mg·L-1]and Cys C[blood(1.86±1.04)mg·L-1]in MBPS group were higher than those of non MBPS group(P<0.05).ConclusionsOf patients with type H hypertension the ones who have morning blood pressure surge were more likely to have early renal damage than those who did not have morning blood pressure surge.