探讨降钙素原在治疗脓毒症患者中的意义

The significance of procalcitonin in the treatment of sepsis

目的探讨脓毒症患者治疗中用降钙素原(PCT)水平来指导临床抗生素使用的意义。方法 60例脓毒症患者分为对照组与治疗组。对照组按常规治疗方法使用抗生素进行治疗,治疗组通过检测血清PCT浓度来指导抗生素使用。比较两组患者炎性指标:PCT治疗前后之间的差异及两组治疗抗生素使用时间费用及入住重症监护病房(ICU)时间的差异。结果两组经治疗后,治疗组抗生素使用天数、费用及入住ICU时间均明显低于对照组,差异有统计学意义(t=8.37,6.27,7.24,P<0.05)。结论脓毒症患者治疗中采用PCT浓度水平用药可以取得更好的治疗结果,减少入住ICU时间,减轻患者经济负担,值得临床推广。

ObjectiveTo investigate the significance of the level of procalcitonin(PCT)to guide the use of antibiotics in the treatment of sepsis.MethodsSixty patients with sepsis were randomly assigned into control group and PCT treatment group.The control group received routine treatment using antibiotic treatment while PCT group guided the use of antibiotics by detecting serum PCT concentration.Inflammatory indexes between the two groups were compared:PCT differences between before and after treatment,antibiotic treatment time and intensive care unit(ICU)time cost.ResultsAfter treatment,in the treatment group antibiotics use,cost,and duration of stay in ICU were significantly lower than those in the control group;the differences were statistically significant(t=8.37,6.27,724,respectively,P<0.05).ConclusionsSepsis patients were treated according to PCT levels,which can achieve better drug treatment effects,reduce the ICU admission time and the economic burden of patients.It was worthy of clinical application.