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细胞黏附分子Neuroplastin功能的研究进展

Research progress in neuroplastin as cell adhesion molecule
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摘要 Neuroplastin(np)是属于免疫球蛋白超家族、富含于突触膜的细胞黏附分子,有np65和np55两种异构体。np65是脑特异性的,np55是全身分布的。Neuroplastin可在长时程增强、突触可塑性和促进神经突起生长等方面发挥作用,可能与学习、记忆、情感有关。本文对Neuroplastin的结构、分布和功能进行综述。 Neuroplastin(np)belonging to the immunoglobulin(Ig)superfamily,is a synapse enriched adhesion molecule.There are two isomers of neuroplastin,named np65and np55according to their molecular weight;np65is brain specific,while np55is widely distributed in various tissues.Neuroplastinsins played a role in long term potential,synaptic plasticity and promoting neurite outgrowth,which may be associated with learning,memory and mood.In this review,the molecular structure,distribution and biological functions of neuroplastins are focused.
作者 乔梦 袁琼兰 QIAO Meng;YUAN Qiong-lan(Dept.of Anatomy and Neurobiology, School of Medicine, Tongji University, Shanghai 200092,China)
机构地区 同济大学医学院解剖学与神经生物学教研室
出处 《同济大学学报（医学版）》 CAS 2017年第5期113-118,共6页 Journal of Tongji University(Medical Science)
基金 国家自然科学基金(81371213 81070987 30971531) 上海市大学生创新项目(1500107066)
关键词 Neuroplastin 细胞黏附 神经突起生长 突触可塑性 情感 Neuroplastin cell adhesion neurite growth synaptic plasticity mood
分类号 R741 [医药卫生—神经病学与精神病学]
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  • 2Willmott T, Skitsa I, Hill I, et al. Molecular characterization and structural relationship of the synapse-enriched glycoproteins gp65 and gp55 [J]. J Neurochem, 1992,58 (6) : 2037 - 2043.
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  • 4Smalla KH, Matthies H, Langnase K, et al. The synaptic glycoprotein neuroplastin is involved in long- term potentiation at hippocampal CA1 synapses [J]. Proc Natl Acad Sci U S A, 2000,97(8) : 4327 -4332.
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同济大学学报（医学版）
2017年 第5期

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