雌激素在绝经后干眼治疗中的研究进展

Research progress on treatment of dry eye in postmenopausal women with estrogen

干眼的发病主要与炎症、细胞凋亡、性激素失调等有关,绝经后女性干眼的发病率明显升高。眼表组织如睑板腺、泪腺、角膜及结膜组织上均有雌激素受体的分布,这可能是眼表组织作为雌激素作用靶器官的原因。激素替代治疗是目前治疗绝经后干眼的方法之一,主要以雌激素及雌孕激素联合应用为主,但是激素替代治疗的有效性及安全性仍然存在争议。本文就雌激素在绝经后干眼治疗中的研究进展进行综述。

The pathogenesis of dry eye includes inflammation,apoptosis,sex hormone disorders and so on.The incidence of dry eye in postmenopausal women increases significantly.The meibomian glands,lacrimal glands,cornea and conjunctiva contain estrogen receptors,suggesting that ocular tissues may act as the target organs of estrogen.Hormone replacement therapy with estrogen alone or combined with progesterone,is one of the methods for treatment of dry ey e,but its efficacy and safety remain uncertain.This article reviews the progress on treatment of dry eye in postmenopausal women with estrogen.