焦虑抑郁情绪对支气管哮喘患者肺功能、气道炎症及重塑的影响

Effect of anxiety and depression on pulmonary function as well as airway inflammation and remodeling in patients with bronchial asthma

目的:探讨焦虑抑郁情绪对支气管哮喘患者肺功能、气道炎症及重塑的影响。方法:选取在本院接受治疗的成人支气管哮喘患者118例,根据抑郁自评量表(SDS)、焦虑自评量表(SAS)评分将其分为单纯抑郁组30例、单纯焦虑组47例、抑郁联合焦虑组19例、心理健康组22例。对比四组患者的肺功能参数水平及血清炎症因子、气道重塑指标含量的差异。结果:单纯抑郁组、单纯焦虑组、抑郁联合焦虑组患者FEV1、PEF、FVC的水平以及血清中TIMP-1的含量低于心理健康组患者,血清中IL-2、IL-4、IL-8、IL-33、VEGF、OPN、TGF-β1、MMP-9的含量高于心理健康组患者且抑郁联合焦虑组患者FEV1、PEF、FVC的水平以及血清中TIMP-1的含量低于单纯抑郁组、单纯焦虑组,血清中IL-2、IL-4、IL-8、IL-33、VEGF、OPN、TGF-β1、MMP-9的含量高于单纯抑郁组、单纯焦虑组。结论:焦虑、抑郁情绪可加剧支气管哮喘患者的肺功能损伤,增加气道炎症程度、促进气道重塑进程。

Objective:To study the effect of anxiety and depression on pulmonary function as well as airway inflammation and remodeling in patients with bronchial asthma.Methods:A total of118adult patients with bronchial asthma who were treated in our hospital were divided into pure depression group(n=30),pure anxiety group(n=47),depression+anxiety group(n=19)and mental health group(n=22)according to the Self Rating Depression Scale(SDS)and Self rating Anxiety Scale(SAS)score.The differences in the levels of pulmonary function parameters as well as the contents of serum inflammatory factors and airway remodeling indexes were compared among the four groups.Results:FEV1,PEF and FVC levels as well as serum TIMP1contents of pure depression group,pure anxiety group and depression+anxiety group were lower than those of mental health group while serum IL2,IL4,IL8,IL33,VEGF,OPN,TGFβ1and MMP9contents were higher than those of mental health group,and FEV1,PEF and FVC levels as well as serum TIMP1content of depression+anxiety group were lower than those of pure depression group and pure anxiety group while serum IL2,IL4,IL8,IL33,VEGF,OPN,TGFβ1and MMP9contents were higher than those of pure depression group and pure anxiety group.Conclusion:Anxiety and depression can aggravate the pulmonary function injury,increase airway inflammation and promote airway remodeling process in patients with bronchial asthma.