2型糖尿病患者焦虑状态与血糖控制情况、微炎症及氧化应激状态的相关性研究

Correlation of anxiety state with blood glucose control,microinflammation and oxidative stress in patients with type 2 diabetes mellitus

目的:探讨2型糖尿病患者焦虑状态与血糖控制情况、微炎症及氧化应激状态的相关性。方法:138例2型糖尿病患者根据焦虑自评量表(SAS)评分值分为非焦虑组(SAS评分<50分)43例、轻中度焦虑组(SAS评分50~69分)71例、重度焦虑组(SAS评分≥70分)24例。对比三组患者糖代谢指标、微炎症指标、氧化应激指标水平的差异。结果:轻中度焦虑组、重度焦虑组患者外周血中FPG、P2hPG、HOMA-IR、CRP、ASAA、IL-6、MDA、ROS的水平均高于非焦虑组,CAT、GSH-Px的含量低于非焦虑组;重度焦虑组患者外周血中FPG、P2hPG、HOMA-IR、CRP、ASAA、IL-6、MDA、ROS的水平均高于轻中度焦虑组,CAT、GSH-Px的含量低于轻中度焦虑组。结论:2型糖尿病患者焦虑程度增加是导致糖代谢异常、微炎症状态及氧化应激状态加剧的直接因素。

Objective:To study the correlation of anxiety state with blood glucose control,microinflammation and oxidative stress in patients with type2diabetes mellitus.Methods:A total of138patients with type2diabetes mellitus were divided into the non anxiety group(n=43)(SAS score<50points),mild to moderate anxiety group(n=71)(SAS score50~69points)and severe anxiety group(n=24)(SAS score≥70points)according to the self rating anxiety scale(SAS)score.The differences in levels of glucose metabolism indexes,microinflammation indexes and oxidative stress indexes were compared among the three groups.Results:Peripheral blood FPG,P2hPG,HOMA IR,CRP,ASAA,IL6,MDA and ROS levels of mild to moderate anxiety group and severe anxiety group were higher than those of non anxiety group while CAT and GSH Px contents were lower than those of non anxiety group;peripheral blood FPG,P2hPG,HOMA IR,CRP,ASAA,IL6,MDA and ROS levels of severe anxiety group were higher than those of mid to moderate anxiety group while CAT and GSH Px contents were lower than those of mid to moderate anxiety group.Conclusion:The increase of anxiety in patients with type2diabetes mellitus is a direct factor leading to the abnormal glucose metabolism as well as the aggravation of microinflammatory state and oxidative stress state.