射频联合阿霉素治疗神经病理性疼痛的疗效观察及安全性评价

Clinical efficacy and safety evaluation of radiofrequency ablation combined with doxorubicin in the treatment of neuropathic pain

目的:探讨射频联合阿霉素治疗神经病理性疼痛的临床疗效及其安全性。方法:神经病理性疼痛病人60例,依据随机数字表法随机分为观察组30例与对照组30例。对照组采用常规西医治疗,观察组采用射频联合阿霉素治疗。2组疗程均为4周。比较2组病人治疗疗效,治疗后疼痛改善情况和睡眠改善情况及不良反应发生情况。结果:观察组治疗总有效率高于对照组(P<0.05);2组疼痛视觉模拟评分治疗后均下降(P<0.05),观察组疼痛视觉模拟评分治疗后低于对照组(P<0.05);2组睡眠评分治疗后均下降(P<0.05),观察组睡眠评分治疗后低于对照组(P<0.05);2组均未见严重不良反应。结论:射频联合阿霉素注射液治疗神经病理性疼痛临床疗效显著,且安全性良好,值得研究。

Objective:To investigate the clinical efficacy and safety of radiofrequency ablation combined with doxorubicin in the treatment of neuropathic pain.Methods:Sixty neuropathic pain patients were randomly divided into the observation group and control group(30cases each group).The control group were treated with conventional Western medicine,and the observation group were treated with radiofrequency ablation combined with doxorubicin for4weeks(2courses).The clinical efficacy of two groups,pain and sleep improvement after treatment and incidence of adverse events between two groups were compared.Results:The total effective rate in observation group was higher than that in control group(P<0.05).The visual analog scale score in two groups decreased after treatment(P<0.05),and the visual analog scale score in observation group after treatment was lower than that in control group(P<0.05).The scores of sleep in two groups after treatment decreased(P<0.05),and the sleep score in observation group after treatment was lower than that in control group(P<0.05).No serious adverse reaction was found in two groups.Conclusions:The treatment of neuropathic pain with radiofrequency ablation combined with adriamycin injection is effective and safe.