左西替利嗪联合孟鲁司特治疗儿童慢性特发性荨麻疹的疗效观察

Effect of levocetirizine combined with montelukast in the treatment of chronic idiopathic urticarial in children

目的:观察盐酸左西替利嗪联合孟鲁司特治疗儿童慢性特发性荨麻疹(CIU)的疗效及安全性。方法:选取94例CIU患儿,随机分成观察组和对照组(各47例)。2组均采用口服盐酸左西替利嗪口服液,其中观察组同时加用孟鲁司特钠咀嚼片,疗程为28 d,分别在治疗后第14天与第28天时采用症状体征积分观察疗效,同时记录不良反应事件,在停药后6周及12周后进行随访。结果:观察组患儿在治疗第14天及第28天时,总有效率分别为74.5%及87.2%,均高于对照组的55.3%和70.2%(P<0.05)。经治疗后第14天与第28天,2组患儿的主要临床症状体征评分均明显低于治疗前(P<0.01),治疗后第14天及第28天观察组风团持续发作时间及发作频率评分均显著少于对照组(P<0.01),观察患儿停药后第6周及第12周复发率分别为12.8%及17.0%,均低于对照组的29.8%和36.2%(P<0.05)。对照组和观察组的不良反应发生率分别为10.6%及8.51%,差异无统计学意义(P>0.05)。结论:西替利嗪联合应用孟鲁司特治疗儿童慢性特发性荨麻疹安全、有效,其疗效及复发率均优于单用左西替利嗪,值得在临床上推广运用。

Objective:To evaluate the efficacy and safety of levocetirizine combined with montelukast in the treatment of chronic idiopathic urticaria(CIU)in children.Methods:Ninety four children with CIU were randomly divided into the observation group(47cases)and control group(47cases).Two groups were treated with levocetirizine by oral for28days.The observation group were additionally treated with montelukast for28days.The efficacy in two groups were observed after14and28days of treatment using the scores of symptoms and signs,and the adverse events were recorded.All cases were followed up after6weeks and12weeks of stopping treatment.Results:The effective rates in observation group on14th day and28th day(74.5%and87.2%)were higher than those in control group(55.3%and70.2%),respectively(P<0.05).After treatment,the scores of symptoms and signs in two groups were obviously lower than those before treatment(P<0.01),and the wheal occurrence and duration in observation group were significantly less than those in control group on14th day and28th day(P<0.01).The recurrence rates in observation group after6weeks and12weeks of stopping treatment(12.8%and17.0%)were lower than those in control group(29.8%and36.2%),respectively(P<0.05).The incidence rates of adverse reaction in control group and observation group were10.6%and8.51%,respectively,and the difference of which between two groups was not statistically significant(P>0.05).Conclusions:Compared with levocetirizine,the treatment of CIU with levocetirizine combined with montelukast is safe,effective and less recurrence rate,which is worthy of popularization and application.