小儿紫癜疹消颗粒对过敏性紫癜患儿临床疗效及对白细胞介素4、6水平的影响

Clinical effect of Pediatric Purpura Rash Elimination Particles on children with Henoch Schonlein purpura and its influence on the levels of IL-4 and IL-6

目的观察紫癜疹消颗粒对过敏性紫癜患儿的临床疗效及对白细胞介素4、6水平的影响。方法选取2016年1月至12月在长春中医药大学附属医院儿科门诊和住院部就诊的过敏性紫癜患儿60例,随机分为观察组和对照组各30例。对照组给予清热解毒中药喜炎平注射液、维生素C、10%葡萄糖酸钙注射液等药物静脉滴注对症支持治疗。观察组在对照组治疗基础上口服小儿紫癜疹消颗粒,疗程共7d。采用酶联免疫吸附法检测白细胞介素4和白细胞介素6。治疗后观察两组临床疗效及白细胞介素4、6变化情况。结果观察组总有效率为93.3%(28/30),显著高于对照组73.3%(22/30),差异有统计学意义(P<0.05)。两组患儿治疗后血清白细胞介素4及白细胞介素6水平均低于治疗前,差异有统计学意义(P<0.05);观察组治疗后血清白细胞介素4及白细胞介素6水平均显著低于对照组,差异有统计学意义(P<0.05)。结论小儿紫癜疹消颗粒治疗过敏性紫癜疗效显著,且可能调节白细胞介素4、6水平。

ObjectiveTo observe the clinical effect of Pediatric Purpura Rash Elimination Particles on children with Henoch Schonlein purpura and its influence on the levels of IL-4and IL-6.MethodsA total of60children with Henoch Schonlein purpura were selected from Outpatient Department of Pediatrics and Inpatient Department of Changchun University of TCM Affiliated Hospital,who were treated from January2016to December.They were divided into observation group and control group with30cases in each group according to random number table method.The control group was given Xiyanping injection and vitamin C,10%calcium gluconate injection for intravenous symptomatic treatment.On the basis of the treatment for the control group,Pediatric Purpura Rash Elimination Particles was used in the observation group,the course of treatment lasting for7d.IL-4and IL-6were detected by enzyme linked immunosorbent assay(ELISA).After treatment,the clinical efficacy and the changes of IL-4and IL-6in the two groups were observed.ResultsThe total effective rate of the observation group was93.3%(28/30),which was significantly higher than that of the control group73.3%(22/30),and the difference was statistically significant(P<0.05).The average serum level of IL-4and IL-6was lower after treatment in the two groups than before treatment,the difference being statistically significant(P<0.05);in the observation group after treatment,serum level of IL-4and IL-6was significantly lower than the control group,the difference being statistically significant(P<0.05).ConclusionThe effect of Pediatric Purpura Rash Elimination Particles is remarkable,which may adjust IL-4and IL-6levels.