降钙素原在乳腺癌化疗中的诊断价值分析及乳腺癌的感染特点探讨

Discussion on the diagnostic value of procalcitonin in breast cancer chemotherapy and infection characteristics of breast cancer

目的分析乳腺癌化疗后粒细胞减少伴发热(FN)合并感染的临床特点及降钙素原在FN合并感染患者中的诊断价值。方法选取2015年10月~2017年8月乳腺癌化疗后粒细胞减少伴发热(FN)合并感染的患者20例为观察组,另外选择非感染患者20例为对照组,分析乳腺癌化疗后粒细胞减少伴发热(FN)合并感染的临床特点,分别测定两组降钙素原的水平并进行比较。结果分析乳腺癌化疗后粒细胞减少伴发热(FN)合并感染的部位包括呼吸道、泌尿道和消化道,导致感染的病原菌包括大肠埃希菌、金黄色葡萄球菌和肺炎克雷伯杆菌。观察组的降钙素原水平明显高于对照组,差异有统计学的意义(P<0.05)。结论乳腺癌化疗后粒细胞减少伴发热(FN)合并感染影响化疗的效果,需要进行预防管理,降钙素原可用于乳腺癌化疗后粒细胞减少伴发热(FN)合并感染的诊断。

Objective To analyze the clinical characteristics of granulocytopenia complicated with fever(FN)concurrent infection after breast cancer chemotherapy and the diagnostic value of procalcitonin in the patients with FN concurrent infection.Methods20patients with granulocytopenia complicated with fever(FN)concurrent infection after breast cancer chemotherapy from October2015to August2017were selected as the observation group,and another20patients without infections were selected as the control group.The clinical characteristics of granulocytopenia complicated with fever(FN)concurrent infection after breast cancer chemotherapy was analyzed,and the levels of procalcitonin were measured and compared between the two groups.Results The part of granulocytopenia complicated with fever(FN)concurrent infection after breast cancer chemotherapy was analyzed,including the respiratory tract,urinary tract and digestive tract.The pathogens leading to infection was analyzed,including escherichia coli,staphylococcus aureus and Klebsiella pneumoniae.The level of procalcitonin in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of granulocytopenia complicated with fever(FN)concurrent infection after breast cancer chemotherapy on chemothepray is in need of prevention management.Procalcitonin can be used for the diagnosis of granulocytopenia complicated with fever(FN)concurrent infection after breast cancer chemotherapy.