支气管哮喘治疗中临床药学监护及合理用药分析的临床应用研究

Clinical application of clinical pharmacological monitoring and rational drug analysis in treatment of bronchial asthma

目的研究支气管哮喘治疗中临床药学监护及合理用药分析的临床应用。方法随机抽取2015年1月~2017年5月收治的50例支气管哮喘患儿设为研究对象,根据随机数字表法将50例患儿分成两组,其中25例患儿应用常规药物进行治疗设为对照组,另外25例患儿应用常规药物治疗同时配合药学监护,同时分析药物应用的合理性设作观察组,对比两组治疗效果和肺功能指标、住院时间、不良反应等情况。结果观察组用药种类有头孢唑肟和特布他林、二羟丙茶碱及茶碱缓释片,治疗效果明显高于对照组(P<0.05);治疗前两组肺功能指标(FEV1、FEV1/FVC、PEF)对比无显著差异(P>0.05);治疗后观察组肺功能指标明显比对照组高,两组对比差异有统计学意义(P<0.05);观察组住院时间比对照组短,两组对比差异有统计学意义(P<0.05);观察组不良反应发生率比对照组低,两组对比差异有统计学意义(P<0.05)。结论支气管哮喘患儿临床用药治疗过程中配合临床药学监护及合理用药分析可以更好的改善患儿的肺功能各项指标,从而提高治疗效果,减少不良反应发生,值得推广应用。

Objective To study the clinical application of clinical pharmacological monitoring and rational drug analysis in the treatment of bronchial asthma.Methods50children with bronchial asthma from January2015to May2017were randomly selected.The children were divided into two groups according to the random number table method.25children in the control group were treated with conventional drugs.The25children in the observation group were treated with conventional drug therapy combined with pharmacological monitoring and the rationality of drug application was analyzed.The treatment effect,lung function index,hospitalization time and adverse reactions were compared between the two groups.Results The therapeutic effects of drugs including cefazoxime and terbutaline,dicloxyprolide theophylline and theophylline sustained release tablets were significantly higher than those in the control group(P<0.05).There were no significant differences in the pulmonary function indexes(FEV1,FEV1/FVC,PEF)of the two groups before treatment.The pulmonary function indexes of the observation group were better than those of the control group,and the difference between the two groups was significant(P<0.05).The time of hospitalization in the observation group was shorter than that in the control group,and the difference was significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference between the two groups was significant(P<0.05).Conclusion The clinical pharmacological monitoring and rational drug use in the treatment of children with bronchial asthma can improve the indexes of lung function in children better,so as to improve the therapeutic effect and reduce the occurrence of adverse reactions,which is worthy of promotion and application.