摘要
目的探讨干眼的危险因素及发生频率。方法 564例(564眼)纳入研究,采用问卷调查的方式对研究对象干眼的症状、体征及全身情况进行评估。采用SPSS 16.0统计学软件分析数据,χ2和t检验进行组间差异分析,Logistic回归分析危险因素和干眼的关系。结果口干与重症干眼的症状(OR=2.89,95%CI:1.6~5.5,P=0.001)有相关性。使用胃溃疡药物加重重症干眼的症状(OR=2.60,95%CI:1.1~5.1,P=0.04)。使用人工泪液加重重症干眼体征(OR=2.1,95%CI:1.2~3.2,P=0.01)。口干(OR=1.92,95%CI:1.02~3.60,P=0.04)及使用利尿剂(OR=6.00,95%CI:1.3~41.0,P=0.02)均为泪液分泌障碍的危险因素。年龄较大(OR=1.02,95%CI:1.05~1.09,P=0.000)、男性(OR=1.42,95%CI:1.04~2.60,P=0.02)、关节炎(OR=8.00,95%CI:1.0~59.0,P=0.02)和使用降压药(OR=2.85,95%CI:1.3~5.7,P=0.01)为睑板腺功能障碍的危险因素。口干是角膜染色的危险因素(OR=2.21,95%CI:1.1-5.4,P=0.02)。结论不同的危险因素对干眼影响不同,表明干眼的不同亚型具有不同病理生理机制。
ObjectiveTo explore the risk factors for dry eye(DE)and its incidence.MethodsTogether564patients(564eyes)were included in the study,and questionnaires were used to evaluate the symptoms,signs and general condition of the subjects with dry eye.Data were analyzed by using SPSS16.0software.χ2test and t test were used to analyze the differences among groups,and logistic regression analysis was used to evaluate the relationship between risk factors and dry eye.ResultsFactors were significantly associated with increased severe DE symptoms included dry mouth(OR=2.89,95%CI:1.6-5.5;P=0.001)and gastrointestinal ulcer medications(OR=2.60,95%CI:1.1-5.1;P=0.04).In addition,administration of artificial tears could aggravate the signs of severe dry eye(OR=2.1,95%CI:1.2-3.2;P=0.01).Risk factors associated with aqueous tear deficiency were dry mouth(OR=1.92,95%CI:1.02-360;P=0.04)and diuretics(OR=6.00,95%CI:1.3-41.0;P=0.02).Risk factors associated with meibomian gland dysfunction included old age(OR=1.02,95%CI:1.05-1.09;P=0.000),male sex(OR=1.42,95%CI:1.04-2.6;P=0.02),arthritis(OR=800,95%CI:1.0-59.0;P=0.02),and administration of an antihypertensive drugs(OR=285,95%CI:1.3-5.7;P=0.01).The only risk factor associated with corneal staining was dry mouth(OR=2.21,95%CI:1.1-5.4;P=0.02).ConclusionDifferent risk factors have different effects on dry eye,indicating that different subtypes of dry eye have different pathophysiological mechanisms.
作者
袁媛
YUAN Yuan(the Department of Ophthalmology,the Second People’s Hospital of Nantong,Nantong 226002,Jiangsu Province,China)
出处
《眼科新进展》
CAS
北大核心
2017年第12期1173-1177,共5页
Recent Advances in Ophthalmology
关键词
干眼
睑板腺功能障碍
眼表疾病
dry eye
meibomian gland dysfunction
ocular surface diseases