原发性颅内软骨肉瘤2例报告及文献复习

Primary intracranial chondrosarcoma:A report of 2 cases and literature review

目的:分析2例原发性颅内软骨肉瘤患者的临床资料,提高对该病的认识和管理。方法:患者1因左眼动眼神经瘫入院,术前考虑为颅咽管瘤,术后给予放疗。患者2因视力下降入院,术前考虑为脊索瘤,行肿瘤大部分切除。结果:2例患者术后病理均证实为软骨肉瘤。患者1术后症状缓解,随访至今未见明显进展;患者2术后第10天因发生严重颅内感染而死亡。结论:原发性颅内软骨肉瘤术前极易误诊,需通过术后病理确诊,手术是首选治疗方案,术后辅以放疗可以取得较好疗效。

Objective:To analyze the clinical data of2patients with primary intracranial chondrosarcoma,and to improve its climical awareness and management Methods:One patient admitted to the hospital because of his left eye with oculomotor palsy,and he was considered as craniopharyngioma before operation and received radiotherapy after operation.The other patient admitted to the hospital for the vision loss,and he was considered as chordoma and received subtotal resection.Results:Both two patients were confirmed as chondrosarcoma by postoperative pathological examination.One patient’s clinical symptoms relieved after operation,and there was no obvious progress from the begining of follow up to now;the other patient died of severe intracranial infection on the10th day after operation.Conclusion:Primary intracranial chondrosarcoma is easy to be misdiagnosed before operation and needs to be confirmed by postoperative pathology.Operation is the first choice for its treatment,and the postoperative radiotherapy can achieve the good results.