卵巢癌相关lncRNA及其与microRNA相互作用

Long non-coding RNAs in ovarian cancer and theirs interaction and microRNAs

卵巢癌是妇科恶性肿瘤的首要致死原因。因为卵巢癌发生、发展无明显症状,常常诊断时已处在难治愈的晚期阶段,而卵巢癌普遍反复产生的耐药性及病程中易复发转移,使得治疗效果往往很差,更敏感和更高效的诊断方法和治疗生物靶点有待被发现。近年来,长链非编码RNA(lncRNAs)成为肿瘤学领域的研究热点,在多种人类恶性肿瘤中显示出其可作为诊断和治疗的新兴生物标志物的潜力。本文着眼于近年来一些与卵巢癌相关的lncRNA的研究,并分析这些lncRNA在卵巢癌发生和发展中扮演的角色,及其与相关microRNA在卵巢癌进程中相互作用的情况,对相关研究进展作一综述。

Ovarian cancer is the leading cause of death among gynecologic malignancies.Since ovarian cancer develops asymptomatically,it is often diagnosed at an advanced and terminal stage.Generally,recurrent drug-resistant tumors and metastasis reduce the treatment’s efficacy,therefore more sensitive and efficient diagnostic methods and therapeutic biological targets are to be developed.Recently,lncRNAs have been highlighted in oncology research fields,showing their potential as an emerging biomarker in the diagnosis and treatment of various human malignancies.In this review,we have summarized several studies about lncRNAs involved in ovarian cancer and analyzed their roles in the tumorigenesis and development of ovarian cancer as well as the interaction between these lncRNAs and related microRNAs in disease progression.